Department of Cardiology, University Hospital Gent, Gent, Belgium.
Department of Cardiology, University Hospital Gent, Gent, Belgium.
Trends Cardiovasc Med. 2020 Feb;30(2):115-122. doi: 10.1016/j.tcm.2019.03.008. Epub 2019 Apr 8.
Cardiac resynchronization therapy (CRT) has been a major step in the treatment of heart failure patients and intraventricular conduction delay. As a considerable number of patients do not respond adequately to CRT, echocardiographic dyssynchrony selection criteria have been proposed to improve CRT response, but these parameters eventually failed to provide superior selection of CRT candidates. In the last decade, an echo-dyssynchrony parameter called "septal flash" was been reported by several investigators and opinion leaders in the field of CRT. This parameter has a strong pathophysiological rationale and was shown to be a robust and predominant predictor of CRT response in recent observational and retrospective studies. We here provide a comprehensive and balanced overview of septal flash and address several important aspects, questions and potential future implications of septal flash in cardiomyopathy and CRT.
心脏再同步治疗 (CRT) 是心力衰竭患者和室内传导延迟治疗的重要步骤。由于相当数量的患者对 CRT 反应不足，因此提出了超声心动图不同步选择标准以提高 CRT 反应，但这些参数最终未能提供 CRT 候选者的更好选择。在过去十年中，几位 CRT 领域的研究人员和意见领袖报告了一个称为“室间隔闪光”的超声心动图不同步参数。该参数具有很强的病理生理基础，并且在最近的观察性和回顾性研究中显示出是 CRT 反应的一个强大且主要的预测因子。我们在此提供了关于室间隔闪光的全面和平衡的概述，并讨论了室间隔闪光在心肌病和 CRT 中的几个重要方面、问题和潜在的未来影响。
