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Mindbomb同源物-1指标在高级别胶质瘤预后中的意义及其与临床病理的相关性

Mindbomb Homolog-1 Index in the Prognosis of High-Grade Glioma and Its Clinicopathological Correlation.

作者信息

Krishnan Shyam Sundar, Muthiah Shanmugam, Rao Shilpa, Salem Suganthi Srinivasan, Madabhushi Vasudevan Chakravarthy, Mahadevan Anita

机构信息

Department of Neurosurgery, PGINS, ALNC, VHS Hospital, Chennai, Tamil Nadu, India.

Department of Neuropathology, NIMHANS Hospital, Bengaluru, Karnataka, India.

出版信息

J Neurosci Rural Pract. 2019 Apr-Jun;10(2):185-193. doi: 10.4103/jnrp.jnrp_374_18.

DOI:10.4103/jnrp.jnrp_374_18
PMID:31001003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6454943/
Abstract

INTRODUCTION

Gliomas are the most common brain tumors in adults originating from the glial cells. Glioblastoma multiforme is the most malignant and frequent among all gliomas. In recent years, the antibody Mindbomb Homolog-1 (MIB-1) has evolved as a measure of the proliferative nature of the glial tumors. This study aims to investigate the MIB-1 index value as an independent prognostic factor in high-grade gliomas and its correlation with outcome and survival.

MATERIALS AND METHODS

Mean MIB-1 index was determined in 51 high-grade glioma tissue samples in formalin. Its correlation with outcome by assessing the clinicoradiological parameters and median survival of patients in months were assessed. Survival analysis was studied by using the Kaplan-Meier bivariate analysis and Cox proportional ratio.

RESULTS

Preoperative Karnofsky Performance Score, WHO-PS, Neurological Performance Scale, and Mini-Mental Status Examination (MMSE) were statistically significant with respect to outcome and survival, whereas tumor factors such as size and perilesional edema were not. In particular, midline-crossing tumors and deep-seated tumors were significantly associated with high MIB-1 index and by correlation with outcome. There were significantly higher number ( < 0.0001) of patients with Grade IV tumors, with an MIB-1 index value above an arbitrary cutoff of 10% compared to Grade III tumors. In addition, median survival period of patients with low MIB-1 index was longer irrespective of tumor grade.

CONCLUSION

Significant correlation between high-grade glioma and MIB-1 index suggests MIB-1 index to be a good prognostic tool, with MIB-1 index and midline-crossing variables being independent prognostic parameters.

摘要

引言

胶质瘤是成人中最常见的起源于神经胶质细胞的脑肿瘤。多形性胶质母细胞瘤是所有胶质瘤中恶性程度最高且最常见的。近年来，抗体Mindbomb同源物-1（MIB-1）已逐渐成为衡量胶质肿瘤增殖特性的指标。本研究旨在探讨MIB-1指数值作为高级别胶质瘤的独立预后因素及其与预后和生存的相关性。

材料与方法

测定51份福尔马林固定的高级别胶质瘤组织样本中的平均MIB-1指数。通过评估临床放射学参数和患者以月为单位的中位生存期来评估其与预后的相关性。采用Kaplan-Meier双变量分析和Cox比例风险模型进行生存分析。

结果

术前卡氏功能状态评分、世界卫生组织表现状态评分、神经功能量表和简易精神状态检查表（MMSE）在预后和生存方面具有统计学意义，而肿瘤大小和瘤周水肿等肿瘤因素则无统计学意义。特别是，中线交叉肿瘤和深部肿瘤与高MIB-1指数显著相关，并与预后相关。与Ⅲ级肿瘤相比，Ⅳ级肿瘤且MIB-1指数值高于任意设定的10%临界值的患者数量显著更多（<0.0001）。此外，无论肿瘤级别如何，MIB-1指数低的患者中位生存期更长。

结论

高级别胶质瘤与MIB-1指数之间的显著相关性表明MIB-1指数是一种良好的预后工具，MIB-1指数和中线交叉变量是独立的预后参数。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a1/6454943/0541ad61c9db/JNRP-10-185-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a1/6454943/8536670a24a5/JNRP-10-185-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a1/6454943/0541ad61c9db/JNRP-10-185-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a1/6454943/8536670a24a5/JNRP-10-185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a1/6454943/f3e205949d0b/JNRP-10-185-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a1/6454943/4de36cf16635/JNRP-10-185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a1/6454943/51570d359861/JNRP-10-185-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a1/6454943/0541ad61c9db/JNRP-10-185-g005.jpg

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