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一名腹膜透析患者的可治性脑病——头孢吡肟诱发的脑病

A Treatable Encephalopathy in a Peritoneal Dialysis Patient - Cefepime-Induced Encephalopathy.

作者信息

Khoo Ching Soong, Tee Tze Yuan, Tan Hui Jan, Ali Raymond Azman

机构信息

Neurology Unit, Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

出版信息

J Neurosci Rural Pract. 2019 Apr-Jun;10(2):324-326. doi: 10.4103/jnrp.jnrp_315_18.

DOI:10.4103/jnrp.jnrp_315_18
PMID:31001027
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6454930/
Abstract

We report a patient with end-stage renal disease on peritoneal dialysis, who developed encephalopathy after receiving a few doses of cefepime. He recovered clinically and electroencephalographically after having discontinued the culprit agent and undergone hemodialysis. This case highlights the importance of promptly recognizing this reversible encephalopathy, which can lead to the avoidance of unnecessary workup, reduce the length of hospital stay, and thereby improve the patients' outcome.

摘要

我们报告了一名接受腹膜透析的终末期肾病患者,该患者在接受几剂头孢吡肟后发生了脑病。在停用致病药物并进行血液透析后,他在临床和脑电图方面均已康复。该病例凸显了及时识别这种可逆性脑病的重要性,这可避免不必要的检查,缩短住院时间,从而改善患者的预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5e9/6454930/f176526e1e81/JNRP-10-324-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5e9/6454930/55fbfc0c211d/JNRP-10-324-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5e9/6454930/f176526e1e81/JNRP-10-324-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5e9/6454930/55fbfc0c211d/JNRP-10-324-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5e9/6454930/f176526e1e81/JNRP-10-324-g002.jpg

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A Treatable Encephalopathy in a Peritoneal Dialysis Patient - Cefepime-Induced Encephalopathy.一名腹膜透析患者的可治性脑病——头孢吡肟诱发的脑病
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本文引用的文献

1
Cefepime-induced encephalopathy with normal renal function.头孢吡肟诱发的肾功能正常的脑病
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Antibiotic-associated encephalopathy.抗生素相关性脑病
Neurology. 2016 Mar 8;86(10):963-71. doi: 10.1212/WNL.0000000000002455. Epub 2016 Feb 17.
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Cefepime neurotoxicity in the intensive care unit: a cause of severe, underappreciated encephalopathy.重症监护病房中的头孢吡肟神经毒性:严重且未得到充分认识的脑病的一个病因。
Crit Care. 2013 Nov 7;17(6):R264. doi: 10.1186/cc13094.
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Cefepime-related encephalopathy in peritoneal dialysis patients.腹膜透析患者的头孢吡肟相关性脑病。
J Chin Med Assoc. 2011 Feb;74(2):87-90. doi: 10.1016/j.jcma.2011.01.017.
5
Cefepime-induced encephalopathy with triphasic waves in three Asian patients.三名亚洲患者出现头孢吡肟诱发的伴有三相波的脑病。
Ann Acad Med Singap. 2007 Jun;36(6):450-1.
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Cephalosporin-induced nonconvulsive status epilepticus: clinical and electroencephalographic features.头孢菌素诱发的非惊厥性癫痫持续状态:临床及脑电图特征
Epilepsia. 2005 Sep;46(9):1550-2. doi: 10.1111/j.1528-1167.2005.16305.x.
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Severe but reversible encephalopathy associated with cefepime.与头孢吡肟相关的严重但可逆性脑病。
Neurophysiol Clin. 2000 Dec;30(6):383-6. doi: 10.1016/s0987-7053(00)00234-3.
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Relationship between structure and convulsant properties of some beta-lactam antibiotics following intracerebroventricular microinjection in rats.大鼠脑室内微量注射后某些β-内酰胺类抗生素的结构与惊厥特性之间的关系
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