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本文引用的文献

1
Cefepime-induced neurotoxicity: a systematic review.头孢吡肟诱导的神经毒性:系统评价。
Crit Care. 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1.
2
Characterizing Cefepime Neurotoxicity: A Systematic Review.头孢吡肟神经毒性的特征:一项系统评价
Open Forum Infect Dis. 2017 Oct 10;4(4):ofx170. doi: 10.1093/ofid/ofx170. eCollection 2017 Fall.
3
Neurotoxic effects associated with antibiotic use: management considerations.与抗生素使用相关的神经毒性作用:管理注意事项。
Br J Clin Pharmacol. 2011 Sep;72(3):381-93. doi: 10.1111/j.1365-2125.2011.03991.x.
4
Cefepime-induced encephalopathy.头孢吡肟所致脑病
Int J Infect Dis. 2004 Jan;8(1):59-61. doi: 10.1016/j.ijid.2003.09.003.
5
Pharmacokinetics and pharmacodynamics of cefepime in patients with various degrees of renal function.头孢吡肟在不同程度肾功能患者中的药代动力学和药效学
Antimicrob Agents Chemother. 2003 Jun;47(6):1853-61. doi: 10.1128/AAC.47.6.1853-1861.2003.
6
Pathophysiology of septic encephalopathy: a review.脓毒症脑病的病理生理学:综述
Crit Care Med. 2000 Aug;28(8):3019-24. doi: 10.1097/00003246-200008000-00057.
7
Pharmacokinetics of cefepime in subjects with renal insufficiency.头孢吡肟在肾功能不全受试者中的药代动力学。
Clin Pharmacol Ther. 1990 Sep;48(3):268-76. doi: 10.1038/clpt.1990.149.

一名住院患者的脑病奇案:排查异常嫌疑因素

A Curious Case of Encephalopathy in a Hospitalized Patient: Round Up the Unusual Suspects.

作者信息

Boyars Michael E, Boyars Michael C

机构信息

Internal Medicine, University of Texas, Houston, USA.

Internal Medicine, University of Texas Medical Branch, Galveston, USA.

出版信息

Cureus. 2020 Dec 8;12(12):e11970. doi: 10.7759/cureus.11970.

DOI:10.7759/cureus.11970
PMID:33437539
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7791320/
Abstract

This case describes a 52-year-old female who developed encephalopathy after being hospitalized with sepsis from a recently placed Permcath. A grade two decubitus ulcer was also a potential source of infection. Cefepime and Vancomycin were empirically begun, and the patient improved hemodynamically and clinically. She developed encephalopathy on day six of hospitalization. When the Cefepime was discontinued the encephalopathy promptly resolved. The causes of hospital acquired encephalopathy and potential difficulties in making this diagnosis are discussed with special emphasis on Cefepime induced encephalopathy.

摘要

该病例描述了一名52岁女性,她在因最近置入的长期静脉导管发生败血症住院后出现脑病。二级褥疮也是潜在的感染源。经验性地开始使用头孢吡肟和万古霉素,患者的血流动力学和临床状况有所改善。她在住院第六天出现脑病。停用头孢吡肟后,脑病迅速缓解。本文讨论了医院获得性脑病的病因以及做出该诊断的潜在困难,特别强调了头孢吡肟诱发的脑病。