Ul Amin Razi, Ahmedani Muhammad Anis M, Karim Musa, Raheem Ahmed
Cardiology, National Institute of Cardiovascular Diseases, Karachi, PAK.
Miscellaneous, National Institute of Cardiovascular Diseases, Karachi, PAK.
Cureus. 2019 Feb 4;11(2):e4010. doi: 10.7759/cureus.4010.
Introduction The relationship between the duration of diabetes mellitus and coronary artery disease (CAD) is well established. Moreover, the Gensini score system is a reliable assessment tool for the severity of coronary artery disease (CAD). After an extensive literature search, we found that there is a knowledge gap about the relationship between the Gensini score and the duration of diabetes in our population. Therefore, the aim of this study was to find the relationship between the Gensini score and the duration of diabetes in patients undergoing a coronary angiography. Methods A cross-sectional study was conducted among 321 consecutively selected diabetic patients. Clinically diagnosed cases of diabetes on proper anti-diabetic treatment were included in this study. Patients with known severe CAD or history of coronary artery bypass grafting (CABG) surgery or primary coronary intervention (PCI) were excluded from the study. Coronary angiography was performed on all the patients and their Gensini score was calculated using the modified scoring schema. Duration of diabetes and other baseline risk factors were recorded for all patients. The relationship between the Gensini score and the duration of diabetes was assessed by calculating Pearson's correlation coefficient. Results A total of 321 diabetic patients were included in this study, out of which 67.9% (218) were men and mean ± standard deviation age was 56.13 ± 7.67 years ranging between 40 to 70 years with a majority of the patients, 63.9% (205), being under 60 years of age. Along with diabetes, the most commonly observed risk factor was hypertension, which was observed in 77.6% (249) of the patients. Smoking and obesity were also observed in 18.7% (60) and 17.4% (56) of the patients, respectively. A significant positive correlation, 0.55 (p<0.001), was observed between the duration of diabetes and the Gensini scores. The correlation was found to be stronger in older patients (more than 60 years of age) with a correlation coefficient of 0.52 vs. 0.38, and male patients with correlation coefficients of 0.66 vs. 0.34. Conclusion A significant positive correlation between the Gensini score and the duration of diabetes mellitus was observed. This correlation is relatively stronger among male and older patients (more than 60 years of age).
引言 糖尿病病程与冠状动脉疾病（CAD）之间的关系已得到充分证实。此外，Gensini评分系统是评估冠状动脉疾病（CAD）严重程度的可靠工具。在广泛检索文献后，我们发现关于我国人群中Gensini评分与糖尿病病程之间的关系存在知识空白。因此，本研究的目的是找出接受冠状动脉造影的患者中Gensini评分与糖尿病病程之间的关系。
方法 对连续选取的321例糖尿病患者进行横断面研究。本研究纳入了经临床诊断且接受适当抗糖尿病治疗的糖尿病病例。已知患有严重CAD或有冠状动脉旁路移植术（CABG）手术史或原发性冠状动脉介入治疗（PCI）史的患者被排除在研究之外。对所有患者进行冠状动脉造影，并使用改良的评分方案计算其Gensini评分。记录所有患者的糖尿病病程和其他基线风险因素。通过计算Pearson相关系数评估Gensini评分与糖尿病病程之间的关系。
结果 本研究共纳入321例糖尿病患者，其中67.9%（218例）为男性，平均年龄±标准差为56.13±7.67岁，年龄范围在40至70岁之间，大多数患者（63.9%，205例）年龄在60岁以下。除糖尿病外，最常见的风险因素是高血压，77.6%（249例）的患者存在该因素。吸烟和肥胖分别在18.7%（60例）和17.4%（56例）的患者中观察到。糖尿病病程与Gensini评分之间存在显著正相关，相关系数为0.55（p<0.001）。在年龄较大（60岁以上）的患者中相关性更强，相关系数为0.52，而在年龄较小患者中为0.38；男性患者的相关系数为0.66，女性患者为0.34。
结论 观察到Gensini评分与糖尿病病程之间存在显著正相关。这种相关性在男性和年龄较大（60岁以上）的患者中相对更强。
