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肾小球滤过率正常的冠心病患者血清胱抑素-C与冠状动脉病变严重程度的关系

Relationship between serum cystatin-c and coronary lesion severity in coronary artery disease patients with a normal glomerular filtration rate.

作者信息

Pan Junqiang, Sun Xifeng, Zhang Pengjie, Chen Haichao, Lin Jing

机构信息

Department of Cardiology, Xi'an Central Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, College of Medicine, Xi'an, China.

Department of Nephrology, Zibo Central Hospital, Zibo City, China.

出版信息

J Int Med Res. 2021 Jan;49(1):300060520985639. doi: 10.1177/0300060520985639.

DOI:10.1177/0300060520985639
PMID:33435768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7809317/
Abstract

OBJECTIVE

Cardiovascular disease is a major cause of death. This study evaluated the relationship between serum cystatin-c and coronary lesion severity in coronary artery disease (CAD) patients with a normal glomerular filtration rate.

METHODS

Nine hundred and fifty-nine patients were retrospectively included and divided into non-CAD and CAD groups according to coronary angiography results. CAD patients were classified into three groups by Gensini score tertiles. Multivariable logistic regression was used to study the relationship between serum cystatin-c and coronary lesion severity.

RESULTS

Serum cystatin-c levels were significantly higher in CAD patients than in non-CAD patients. Correlation analysis revealed significant correlations between serum cystatin-c levels with the Gensini score and the number of diseased vessels. The area under the receiver operating characteristic curve of serum cystatin-c was 0.544 and 0.555 for predicting a high Gensini score and three-vessel disease, respectively. Multivariate stepwise regression analysis demonstrated that the serum cystatin-c level was an independent predictor of a high Gensini score [odds ratio (OR) = 2.177, 95% confidence interval (CI) 1.140-3.930] and three-vessel disease (OR = 1.845, 95% CI 0.994-3.424) after adjusting for the conventional CAD risk factors.

CONCLUSIONS

Serum cystatin-c was elevated in CAD patients and may be an independent predictor of CAD severity.

摘要

目的

心血管疾病是主要的死亡原因。本研究评估了肾小球滤过率正常的冠心病（CAD）患者血清胱抑素 - c与冠状动脉病变严重程度之间的关系。

方法

回顾性纳入959例患者，根据冠状动脉造影结果分为非CAD组和CAD组。CAD患者根据Gensini评分三分位数分为三组。采用多变量逻辑回归研究血清胱抑素 - c与冠状动脉病变严重程度之间的关系。

结果

CAD患者血清胱抑素 - c水平显著高于非CAD患者。相关性分析显示血清胱抑素 - c水平与Gensini评分和病变血管数量之间存在显著相关性。血清胱抑素 - c预测高Gensini评分和三支血管病变的受试者工作特征曲线下面积分别为0.544和0.555。多变量逐步回归分析表明，在调整传统CAD危险因素后，血清胱抑素 - c水平是高Gensini评分[比值比（OR）=2.177，95%置信区间（CI）1.140 - 3.930]和三支血管病变（OR =1.845，95% CI 0.994 - 3.424）的独立预测因子。

结论

CAD患者血清胱抑素 - c升高，可能是CAD严重程度的独立预测因子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ae/7809317/a7bc28d1e178/10.1177_0300060520985639-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ae/7809317/a23a55c0385c/10.1177_0300060520985639-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ae/7809317/5b5e85f9d4db/10.1177_0300060520985639-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ae/7809317/a7bc28d1e178/10.1177_0300060520985639-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ae/7809317/a23a55c0385c/10.1177_0300060520985639-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ae/7809317/5b5e85f9d4db/10.1177_0300060520985639-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ae/7809317/a7bc28d1e178/10.1177_0300060520985639-fig3.jpg

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