Center for Microbial Ecology and Technology (CMET), Ghent University, Coupure Links 653, 9000 Gent, Belgium.
Trends Microbiol. 2018 Apr;26(4):313-328. doi: 10.1016/j.tim.2017.10.005. Epub 2017 Nov 10.
The development of novel therapies to control diseases caused by antibiotic-resistant pathogens is one of the major challenges we are currently facing. Many important plant, animal, and human pathogens regulate virulence by quorum sensing, bacterial cell-to-cell communication with small signal molecules. Consequently, a significant research effort is being undertaken to identify and use quorum-sensing-interfering agents in order to control diseases caused by these pathogens. In this review, an overview of our current knowledge of quorum-sensing systems of Gram-negative model pathogens is presented as well as the link with virulence of these pathogens, and recent advances and challenges in the development of quorum-sensing-interfering therapies are discussed.
开发新型疗法来控制由抗生素耐药病原体引起的疾病是我们目前面临的主要挑战之一。许多重要的植物、动物和人类病原体通过群体感应来调节毒力，这是一种细菌细胞间通过小分子信号进行的通讯方式。因此，人们正在进行大量的研究工作，以识别和使用群体感应干扰剂来控制这些病原体引起的疾病。在这篇综述中，我们介绍了革兰氏阴性模式病原体群体感应系统的最新知识，以及这些病原体毒力之间的联系，还讨论了群体感应干扰疗法的最新进展和挑战。
