Qadir Muhammad Imran, Anwer Farha
Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Bosan Road, Multan, Pakistan.
Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.
Crit Rev Eukaryot Gene Expr. 2019;29(1):1-15. doi: 10.1615/CritRevEukaryotGeneExpr.2018024760.
Epigenetics is the variation in organisms that occur by changes in gene expression, and it also occurs in the genetic code. The immune system diseases arise from primarily epigenetic changes of obscure etiology. The current studies demonstrate that a portion of the rearrangements are created by the association of epigenetic alterations. For example, acetylation of histones and methylation of DNA are accounted for. These adjustments in DNA likewise showed the impact in mouse models and immune system illnesses in human. Through this review, it could be reasoned that epigenetic tweaks might be a novel restorative approach against these maladies.
表观遗传学是指生物体中因基因表达变化而出现的变异,它也发生在遗传密码中。免疫系统疾病主要源于病因不明的表观遗传变化。目前的研究表明,一部分重排是由表观遗传改变的关联产生的。例如,组蛋白的乙酰化和DNA的甲基化就被提及。DNA的这些调整在小鼠模型和人类免疫系统疾病中也显示出影响。通过这篇综述,可以推断表观遗传调控可能是对抗这些疾病的一种新的治疗方法。