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与组蛋白乙酰化和DNA甲基化相关的表观遗传修饰作为免疫紊乱的关键因素

Epigenetic Modification Related to Acetylation of Histone and Methylation of DNA as a Key Player in Immunological Disorders.

作者信息

Qadir Muhammad Imran, Anwer Farha

机构信息

Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Bosan Road, Multan, Pakistan.

Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.

出版信息

Crit Rev Eukaryot Gene Expr. 2019;29(1):1-15. doi: 10.1615/CritRevEukaryotGeneExpr.2018024760.

Abstract

Epigenetics is the variation in organisms that occur by changes in gene expression, and it also occurs in the genetic code. The immune system diseases arise from primarily epigenetic changes of obscure etiology. The current studies demonstrate that a portion of the rearrangements are created by the association of epigenetic alterations. For example, acetylation of histones and methylation of DNA are accounted for. These adjustments in DNA likewise showed the impact in mouse models and immune system illnesses in human. Through this review, it could be reasoned that epigenetic tweaks might be a novel restorative approach against these maladies.

摘要

表观遗传学是指生物体中因基因表达变化而出现的变异,它也发生在遗传密码中。免疫系统疾病主要源于病因不明的表观遗传变化。目前的研究表明,一部分重排是由表观遗传改变的关联产生的。例如,组蛋白的乙酰化和DNA的甲基化就被提及。DNA的这些调整在小鼠模型和人类免疫系统疾病中也显示出影响。通过这篇综述,可以推断表观遗传调控可能是对抗这些疾病的一种新的治疗方法。

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