Qian Weijun, Yu Chao, Wang Shuai, Niu Aijun, Shi Guangyan, Cheng Yuancui, Xu Ning, Jin Qiangqiang, Jing Xu
Imaging Department, Kaifeng Central Hospital, Kaifeng, China.
Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Front Psychiatry. 2021 Jan 26;11:586904. doi: 10.3389/fpsyt.2020.586904. eCollection 2020.
Persistent symptoms of depression indicate the adaptive involvement of stable molecules in the brain that may be manifested at the level of chromatin remodeling, such as histone acetylation. Former studies have identified alterations in histone acetylation and deacetylation in several animal models about depression. However, the specific histone deacetylases related with depression are needed to be explored. Here, social avoidance behaviors, anxiety-, and depression-like behaviors were all found in mice suffered from chronic social defeat stress. Moreover, we also discovered that the amount of the class II histone deacetylase, HDAC7 rather than HDAC2, was significantly decreased in the nucleus accumbens of defeated mice, which suggested that HDAC7 might be a crucial histone deacetylase in a chronic social defeat stress model. Our data showed that the depressive-like behaviors induced by chronic social defeat stress were associated with HDAC7 reduction in nucleus accumbens. HDAC7 might be a promising therapeutic target for depression.
持续性抑郁症状表明大脑中稳定分子的适应性参与，这可能在染色质重塑水平上表现出来，如组蛋白乙酰化。先前的研究已经在几种抑郁症动物模型中发现了组蛋白乙酰化和去乙酰化的改变。然而，与抑郁症相关的特定组蛋白去乙酰化酶仍有待探索。在这里，遭受慢性社会挫败应激的小鼠出现了社交回避行为、焦虑样行为和抑郁样行为。此外，我们还发现，在遭受挫败的小鼠伏隔核中，Ⅱ类组蛋白去乙酰化酶HDAC7的量显著减少，而不是HDAC2，这表明HDAC7可能是慢性社会挫败应激模型中的关键组蛋白去乙酰化酶。我们的数据表明，慢性社会挫败应激诱导的抑郁样行为与伏隔核中HDAC7的减少有关。HDAC7可能是一个有前途的抑郁症治疗靶点。
