微卫星不稳定性与结直肠癌中 2 型糖尿病呈负相关。
Microsatellite instability is inversely associated with type 2 diabetes mellitus in colorectal cancer.
机构信息
Department of Surgery, Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Tokyo, Japan.
Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.
出版信息
PLoS One. 2019 Apr 19;14(4):e0215513. doi: 10.1371/journal.pone.0215513. eCollection 2019.
BACKGROUND
Microsatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide units in microsatellites. High-frequency MSI (MSI-H) colorectal cancers (CRCs) are known to have different clinicopathological features compared with microsatellite stable (MSS) CRCs. In addition, previous studies have shown that type2 diabetes mellitus (T2DM) is a risk factor for malignant tumors including CRCs. The aim of this study was to investigate the relationship between T2DM and MSI-H colorectal cancer.
METHODS
The study design is a single center, cross-sectional study. Data from a series of 936 patients with CRCs were collected and MSI status was assessed.
RESULTS
In total, 29 (3.1%) and 907 (96.9%) tumors were classified as having MSI-H and low-frequency microsatellite instability or being MSS (MSS), respectively. Of the 936 patients, 275 (29.6%) were associated with T2DM. One (3.4%) of the 29 MSI-H patients and 274 (30.2%) of the 907 MSS patients had T2DM. Thus, the incidence of T2DM was significantly less frequent in MSI-H compared with MSS patients (Fisher's exact test: p = 0.0007).
CONCLUSIONS
We conclude that MSS tumors are significantly more common than MSI-H tumors among individuals with T2DM.
背景
微卫星不稳定性（MSI）是微卫星中重复 DNA 核苷酸单位数量的克隆性变化。高频微卫星不稳定（MSI-H）结直肠癌（CRC）与微卫星稳定（MSS）CRC 相比具有不同的临床病理特征。此外，先前的研究表明 2 型糖尿病（T2DM）是包括 CRC 在内的恶性肿瘤的危险因素。本研究旨在探讨 T2DM 与 MSI-H 结直肠癌之间的关系。
方法
研究设计为单中心、横断面研究。收集了一系列 936 例 CRC 患者的数据，并评估了 MSI 状态。
结果
共有 29 例（3.1%）和 907 例（96.9%）肿瘤分别归类为 MSI-H 和低频微卫星不稳定或 MSS（MSS）。在 936 例患者中，275 例（29.6%）与 T2DM 相关。29 例 MSI-H 患者中有 1 例（3.4%）和 907 例 MSS 患者中有 274 例（30.2%）患有 T2DM。因此，MSI-H 患者的 T2DM 发生率明显低于 MSS 患者（Fisher 精确检验：p = 0.0007）。
结论
我们得出结论，在 T2DM 个体中，MSS 肿瘤明显比 MSI-H 肿瘤更常见。
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