听胰腺癌干细胞 ROR。

Hear Pancreatic Cancer Stem Cells ROR.

机构信息

Department of Translational Molecular Pathology and Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

出版信息

Cell. 2019 Apr 18;177(3):516-518. doi: 10.1016/j.cell.2019.04.002.

DOI:10.1016/j.cell.2019.04.002

PMID:31002791

Abstract

In this issue of Cell, Lytle et al. (2019) integrate functional genomic approaches to identify molecular dependencies of pancreatic cancer stem cells that may be exploited therapeutically. The comprehensive analysis reveals an unexpected role for retinoic acid receptor-related orphan receptor gamma (RORγ), a T-cell-associated transcription factor, in defining the stemness and the aggressive behavior of pancreatic cancer.

摘要

在本期《细胞》杂志上，Lytle 等人（2019）综合了功能基因组方法，鉴定了可能具有治疗潜力的胰腺癌干细胞的分子依赖性。全面的分析揭示了视黄酸受体相关孤儿受体γ（RORγ）——一种与 T 细胞相关的转录因子——在定义胰腺癌的干性和侵袭性行为方面的意外作用。