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揭示肠道细菌毒力因子 Colibactin 在结直肠癌发生中的突变机制

Unveiling the Mutational Mechanism of the Bacterial Genotoxin Colibactin in Colorectal Cancer.

机构信息

Department of Immunology, University of Toronto, Toronto, ON M5B 1W8, Canada.

Department of Immunology, University of Toronto, Toronto, ON M5B 1W8, Canada.

出版信息

Mol Cell. 2019 Apr 18;74(2):227-229. doi: 10.1016/j.molcel.2019.04.007.

DOI:10.1016/j.molcel.2019.04.007
PMID:31002804
Abstract

In a recent issue of Science, Wilson et al. (2019) provide direct evidence that the bacterial-produced colibactin alkylates DNA in vivo, resulting in DNA adducts, which mediates its genotoxic effect. This work reinforces the role of colibactin-producing bacteria in colon cancer pathogenesis.

摘要

在最近一期的《科学》杂志上，威尔逊等人（2019 年）提供了直接证据，表明细菌产生的 colibactin 在体内使 DNA 烷基化，导致 DNA 加合物，从而介导其遗传毒性作用。这项工作强化了产生 colibactin 的细菌在结肠癌发病机制中的作用。

相似文献

[1]
Unveiling the Mutational Mechanism of the Bacterial Genotoxin Colibactin in Colorectal Cancer.

Mol Cell. 2019-4-18

[2]
The human gut bacterial genotoxin colibactin alkylates DNA.

Science. 2019-2-15

[3]
In vitro genotoxicity analyses of colibactin-producing E. coli isolated from a Japanese colorectal cancer patient.

J Toxicol Sci. 2019

[4]
The Food Contaminant Deoxynivalenol Exacerbates the Genotoxicity of Gut Microbiota.

mBio. 2017-3-14

[5]
High iron supply inhibits the synthesis of the genotoxin colibactin by pathogenic Escherichia coli through a non-canonical Fur/RyhB-mediated pathway.

Pathog Dis. 2017-7-31

[6]
Colibactin DNA-damage signature indicates mutational impact in colorectal cancer.

Nat Med. 2020-6-1

[7]
The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin.

mSphere. 2019-10-2

[8]
The genotoxin colibactin exacerbates lymphopenia and decreases survival rate in mice infected with septicemic Escherichia coli.

J Infect Dis. 2014-1-31

[9]
Carriage of Colibactin-producing Bacteria and Colorectal Cancer Risk.

Trends Microbiol. 2020-11

[10]
Shining a Light on Colibactin Biology.

Toxins (Basel). 2021-5-12

引用本文的文献

[1]
Colibactin-induced damage in bacteria is cell contact independent.

mBio. 2025-1-8

[2]
Elucidating the genotoxicity of Fusobacterium nucleatum-secreted mutagens in colorectal cancer carcinogenesis.

Gut Pathog. 2024-9-27

[3]
Benefits and concerns of probiotics: an overview of the potential genotoxicity of the colibactin-producing Nissle 1917 strain.

Gut Microbes. 2024

[4]
Microbial genotoxin-elicited host DNA mutations related to mitochondrial dysfunction, a momentous contributor for colorectal carcinogenesis.

mSystems. 2024-9-17

[5]
Compartmentalization of the host microbiome: how tumor microbiota shapes checkpoint immunotherapy outcome and offers therapeutic prospects.

J Immunother Cancer. 2022-11

[6]
Western-Style Diet, pks Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses From Two Large Prospective Cohort Studies.

Gastroenterology. 2022-10

[7]
Microbe-Driven Genotoxicity in Gastrointestinal Carcinogenesis.

Int J Mol Sci. 2020-10-9

[8]
The influence of blood on the human gut microbiome.

BMC Microbiol. 2020-3-3

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