揭示肠道细菌毒力因子 Colibactin 在结直肠癌发生中的突变机制
Unveiling the Mutational Mechanism of the Bacterial Genotoxin Colibactin in Colorectal Cancer.
机构信息
Department of Immunology, University of Toronto, Toronto, ON M5B 1W8, Canada.
Department of Immunology, University of Toronto, Toronto, ON M5B 1W8, Canada.
出版信息
Mol Cell. 2019 Apr 18;74(2):227-229. doi: 10.1016/j.molcel.2019.04.007.
PMID:31002804
Abstract
In a recent issue of Science, Wilson et al. (2019) provide direct evidence that the bacterial-produced colibactin alkylates DNA in vivo, resulting in DNA adducts, which mediates its genotoxic effect. This work reinforces the role of colibactin-producing bacteria in colon cancer pathogenesis.
摘要
在最近一期的《科学》杂志上，威尔逊等人（2019 年）提供了直接证据，表明细菌产生的 colibactin 在体内使 DNA 烷基化，导致 DNA 加合物，从而介导其遗传毒性作用。这项工作强化了产生 colibactin 的细菌在结肠癌发病机制中的作用。
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