产 Colibactin 菌的携带情况与结直肠癌风险。
Carriage of Colibactin-producing Bacteria and Colorectal Cancer Risk.
机构信息
School of Molecular Cell Biology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel Aviv, Israel.
The Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
出版信息
Trends Microbiol. 2020 Nov;28(11):874-876. doi: 10.1016/j.tim.2020.05.015. Epub 2020 Jun 5.
Colibactin is a genotoxic molecule, produced primarily by Escherichia coli. Colibactin causes DNA damage that may lead to colorectal cancer. Here we review recent advances in the study of colibactin and propose a focus on patients with inflammatory bowel diseases (IBD) who have higher levels of colibactin-producing bacteria in their intestines.
大肠杆菌素是一种遗传毒性分子，主要由大肠杆菌产生。大肠杆菌素可导致 DNA 损伤，从而可能导致结直肠癌。本文综述了大肠杆菌素研究的最新进展，并提出了重点关注肠道内产生大肠杆菌素的细菌水平较高的炎症性肠病（IBD）患者。
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