Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, Hebei, China.
Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, Hebei, China.
Life Sci. 2019 Jun 15;227:30-38. doi: 10.1016/j.lfs.2019.04.039. Epub 2019 Apr 17.
The gradual energy dissipation of all organisms allows adapting to energy demands. Pathological situations of uncured diseases such as cancer, diabetes, and other obesity-related diseases are caused by an abrupt energy imbalance. As an energy sensor, AMP-activated kinase (AMPK) can regulate the cellular energy status. In case of increased energy demands or insufficient nutrient supply, cells digest their own interior, which is called autophagy. AMPK-mediated autophagy regulates various metabolic and physiological processes and is dysregulated in different chronic conditions. Because of AMPK's critical role in physiology and pathology, it is an emerging target for both prevention and treatment of these uncured diseases. This review discusses the multifaceted role of AMPK on cancer cell survival and inhibition mechanism. First, we discuss the dual role of AMPK on cancer progression and suppression, and we discuss how different AMPK subunit combinations influence the tumor progression and suppression. Next, we discuss what could be the centering point of AMPK that supports promotion or inhibition of the cancer cell growth. Furthermore, we review the role of connecting mechanism of AMPK-mediated molecular intermediates on cancer cell survival and inhibition pathways. Finally, we discuss how AMPK can affect DNA damage and repairing mechanisms, and immune response of host cell and cancer cells.
所有生物体的能量逐渐耗散，以适应能量需求。未治愈疾病（如癌症、糖尿病和其他肥胖相关疾病）的病理情况是由突然的能量失衡引起的。作为能量传感器，AMP 激活的蛋白激酶 (AMPK) 可以调节细胞的能量状态。在能量需求增加或营养供应不足的情况下，细胞会消化自身内部，这被称为自噬。AMPK 介导的自噬调节各种代谢和生理过程，并在不同的慢性疾病中失调。由于 AMPK 在生理和病理中的关键作用，它是预防和治疗这些未治愈疾病的新兴靶点。本综述讨论了 AMPK 在癌细胞存活和抑制机制中的多方面作用。首先，我们讨论了 AMPK 在癌症进展和抑制中的双重作用，并讨论了不同的 AMPK 亚基组合如何影响肿瘤的进展和抑制。接下来，我们讨论了 AMPK 的中心点可能是什么，它支持促进或抑制癌细胞生长。此外，我们回顾了 AMPK 介导的分子中间产物的连接机制在癌细胞存活和抑制途径中的作用。最后，我们讨论了 AMPK 如何影响宿主细胞和癌细胞的 DNA 损伤和修复机制以及免疫反应。
