设计基于循环肿瘤 DNA 的肿瘤学介入临床试验。
Designing circulating tumor DNA-based interventional clinical trials in oncology.
机构信息
Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
出版信息
Genome Med. 2019 Apr 19;11(1):22. doi: 10.1186/s13073-019-0634-x.
Circulating tumor (ct) DNA is a powerful tool that can be used to track cancer beyond a single snapshot in space and time. It has potential applications in detecting minimal residual disease and predicting relapse, in selecting patients for tailored treatments, and in revealing mechanisms of response or resistance. Here, we discuss the incorporation of ctDNA into clinical trials.
循环肿瘤 DNA 是一种强大的工具，可以用于在时空之外跟踪癌症。它在检测微小残留疾病和预测复发、选择患者进行针对性治疗以及揭示反应或耐药机制方面具有潜在的应用。在这里，我们讨论了将 ctDNA 纳入临床试验。
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