Jacobsen Rhîan G, Mazloumi Gavgani Fatemeh, Edson Amanda J, Goris Marianne, Altankhuyag Altanchimeg, Lewis Aurélia E
Department of Biological Sciences, University of Bergen, Bergen, 5008, Norway.
NORCE Norwegian Research Center, Bergen, 5008, Norway.
Adv Biol Regul. 2019 May;72:7-21. doi: 10.1016/j.jbior.2019.04.001. Epub 2019 Apr 6.
Biomolecular interactions between proteins and polyphosphoinositides (PPIn) are essential in the regulation of the vast majority of cellular processes. Consequently, alteration of these interactions is implicated in the development of many diseases. PPIn are phosphorylated derivatives of phosphatidylinositol and consist of seven species with different phosphate combinations. PPIn signal by recruiting proteins via canonical domains or short polybasic motifs. Although their actions are predominantly documented on cytoplasmic membranes, six of the seven PPIn are present within the nucleus together with the PPIn kinases, phosphatases and phospholipases that regulate their turnover. Importantly, the contribution of nuclear PPIn in the regulation of nuclear processes has led to an increased recognition of their importance compared to their more accepted cytoplasmic roles. This review summarises our knowledge on the identification and functional characterisation of nuclear PPIn-effector proteins as well as their mode of interactions, which tend to favour polybasic motifs.
蛋白质与多磷酸肌醇（PPIn）之间的生物分子相互作用在绝大多数细胞过程的调节中至关重要。因此，这些相互作用的改变与许多疾病的发生发展有关。PPIn是磷脂酰肌醇的磷酸化衍生物，由七种具有不同磷酸组合的物种组成。PPIn通过经典结构域或短的多碱性基序招募蛋白质来进行信号传导。尽管它们的作用主要记录在细胞质膜上，但七种PPIn中的六种与调节其周转的PPIn激酶、磷酸酶和磷脂酶一起存在于细胞核中。重要的是，与它们更被认可的细胞质作用相比，核PPIn在核过程调节中的作用使得人们对其重要性的认识有所增加。本综述总结了我们对核PPIn效应蛋白的鉴定和功能表征及其相互作用模式的了解，这些相互作用模式倾向于多碱性基序。
