Abe Yuina, Konno Hajime, Yoshida Shotaro, Nishizawa Matsuhiko
Department of Finemechanics,Graduate School of Engineering,Tohoku University,6-6-01 Aramaki Aoba,Sendai 980-8579, Japane-mail:
J Biomech Eng. 2019 Aug 1;141(8). doi: 10.1115/1.4043522.
The electrical response of the skin to mechanical stretches is reported here. The electrical potential difference across the epidermis, i.e., transepidermal potential (TEP) of porcine skin samples subjected to cyclic stretching, was measured in real time to observe electrochemical change in epidermal tissue. In addition to a conventional method of TEP measurement for the whole of skin sample, a probe-type system with a fine-needle salt bridge was used for direct measurement of TEP at a targeted local point of the skin. TEP decreased with the increased mechanical stretches, and the change of TEP was found to be mostly occurred in the epidermis but not dermis nor hypodermis by comparing the results of conventional and the probe-type methods. The observed change of TEP value was quick, reversible, and strain-dependent. Considering from such characteristic behaviors, one of the possible mechanisms of the modulation of TEP would be influence of the streaming potential caused by the fluid flow during the physical deformation of the epidermis.
本文报道了皮肤对机械拉伸的电响应。实时测量了猪皮肤样本在循环拉伸下表皮上的电势差，即经表皮电势（TEP），以观察表皮组织中的电化学变化。除了用于测量整个皮肤样本TEP的传统方法外，还使用了带有细针盐桥的探针型系统来直接测量皮肤目标局部点的TEP。随着机械拉伸增加，TEP降低，通过比较传统方法和探针型方法的结果发现，TEP的变化主要发生在表皮，而非真皮或皮下组织。观察到的TEP值变化迅速、可逆且与应变有关。从这些特征行为考虑，TEP调节的一种可能机制是表皮物理变形过程中流体流动引起的流动电势的影响。
