Department of Finemechanics, Graduate School of Engineering, Tohoku University, Aramaki Aoba, Sendai, Japan.
Department of Dermatology, Graduate School of Medicine, Tohoku University, Seiryo-machi, Sendai, Japan.
PLoS One. 2019 Jul 10;14(7):e0219198. doi: 10.1371/journal.pone.0219198. eCollection 2019.
The light-promoted recovery of epidermal barrier of skin was evaluated by the associated recovery of transepidermal potential (TEP), the potential difference between the surface and dermis of skin, by using porcine skin samples. An accelerated recovery of TEP was observed by irradiation of red light with the irradiance of 40 mW/cm2 and a duration of > 10 min. The influence of the light stimulation to the surroundings (~ 20 mm) was also observed. The irradiations of blue and purple lights were ineffective in accelerating the barrier recovery. These characteristics of the light stimulation would be useful for the design of effective and safe phototherapy devices for skin. The present study proves that the TEP can serve as a spatiotemporal indicator of the epidermal barrier function.
用光照射猪皮样品，通过测量表皮经皮电势（TEP）的恢复情况（TEP 是皮肤表面和真皮之间的电位差），评估光促进皮肤表皮屏障的恢复。用 40mW/cm2 强度的红光照射 10 分钟以上可观察到 TEP 的加速恢复。还观察到光刺激对周围环境（~20mm）的影响。蓝光和紫光的照射并不能加速屏障的恢复。这些光刺激的特性对于设计有效和安全的皮肤光疗设备将非常有用。本研究证明，TEP 可以作为表皮屏障功能的时空指标。
