单克隆抗白细胞介素-2受体抗体的特异性免疫抑制疗法及其与环孢素的协同作用。
Specific immunosuppressive therapy by monoclonal anti-IL 2 receptor antibody and its synergistic action with cyclosporin.
作者信息
Diamantstein T, Volk H D, Tilney N L, Kupiec-Weglinski J
出版信息
Immunobiology. 1986 Sep;172(3-5):391-9. doi: 10.1016/S0171-2985(86)80120-6.
The effects of anti-IL 2R mab treatment on local GVHR and on heterotopic cardiac allograft survival in rats were investigated. Anti IL 2 mab inhibited specifically both GVHR as well as allograft rejection. IL 2R-targeted therapy was superior to that of anti-T helper/inducer cell treatment, as it did not affect T subset distribution and did not reduce the number of circulating T lymphocytes. This therapy when combined with a low subtherapeutic dose of CsA exerted a strongly synergistic effect. The results support the concept of IL 2R-targeted therapy in suppressing undesired immune reactions with limited side effects.
研究了抗白细胞介素2受体单克隆抗体治疗对大鼠局部移植物抗宿主反应（GVHR）及异位心脏同种异体移植物存活的影响。抗白细胞介素2单克隆抗体特异性地抑制了GVHR以及同种异体移植物排斥反应。白细胞介素2受体靶向治疗优于抗T辅助/诱导细胞治疗，因为它不影响T细胞亚群分布，也不减少循环T淋巴细胞数量。这种治疗与低亚治疗剂量的环孢素A（CsA）联合使用时发挥了强烈的协同作用。这些结果支持白细胞介素2受体靶向治疗在抑制不良免疫反应且副作用有限这一概念。
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