Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Graduate School, Yonsei University College of Medicine, Seoul, Republic of Korea.
CNS Neurosci Ther. 2020 Jan;26(1):30-38. doi: 10.1111/cns.13138. Epub 2019 Apr 19.
Recent evidence suggests that the opioid system is implicated in the pathophysiology of alcohol use disorder (AUD). We aimed to examine the genetic influence of opioid receptors on susceptibility to AUD and its clinical and psychological characteristics including harmful drinking behavior and various aspects of impulsivity in AUD patients.
Three μ-opioid receptor gene (OPRM1) variants and two κ-opioid receptor gene (OPRK1) variants were examined in 314 male patients with AUD and 324 male controls. We applied the Alcohol Use Disorders Identification Test (AUDIT), Obsessive Compulsive Drinking Scale (OCDS), and Alcohol Dependence Scale. AUD patients also completed the stop-signal task, delay discounting task, balloon analogue risk task, and the Barratt Impulsiveness Scale version 11 (BIS-11).
No significant differences in genotype distributions or haplotype frequencies were found between AUD patients and controls. However, OPRK1 SNP rs6473797 was significantly related to the severity of alcohol-related symptoms as measured by AUDIT and OCDS and a haplotype containing rs6473797 was also related to OCDS scores in AUD patients. For other psychological traits, OPRM1 SNP rs495491 was significantly associated with scores on the motor subfactor of the BIS-11.
Genetic variations in opioid receptors may contribute to symptom severity and impulsivity in AUD patients.
最近的证据表明，阿片系统参与了酒精使用障碍（AUD）的病理生理学。我们旨在研究阿片受体的遗传影响对 AUD 易感性及其临床和心理特征的影响，包括 AUD 患者的有害饮酒行为和冲动的各个方面。
在 314 名男性 AUD 患者和 324 名男性对照中检查了 3 种μ-阿片受体基因（OPRM1）变体和 2 种κ-阿片受体基因（OPRK1）变体。我们应用了酒精使用障碍识别测试（AUDIT）、强迫性饮酒量表（OCDS）和酒精依赖量表。AUD 患者还完成了停止信号任务、延迟折扣任务、气球模拟风险任务和巴瑞特冲动量表第 11 版（BIS-11）。
在基因型分布或单倍型频率方面，AUD 患者和对照组之间没有显著差异。然而，OPRK1 SNP rs6473797 与 AUDIT 和 OCDS 测量的酒精相关症状严重程度显著相关，包含 rs6473797 的单倍型也与 AUD 患者的 OCDS 评分相关。对于其他心理特征，OPRM1 SNP rs495491 与 BIS-11 的运动子因素评分显著相关。
阿片受体的遗传变异可能导致 AUD 患者的症状严重程度和冲动性。
