Gifford Jayson R, Bloomfield Travis, Davis Trevor, Addington Amy, McMullin Erin, Wallace Taysom, Proffit Meagan, Hanson Brady
Department of Exercise Sciences, Brigham Young University, Provo, Utah.
Program of Gerontology, Brigham Young University, Provo, Utah.
Physiol Rep. 2019 Apr;7(8):e14064. doi: 10.14814/phy2.14064.
Passive leg movement (PLM)-induced hyperemia is used to assess the function of the vascular endothelium. This study sought to determine the impact of movement speed and range of motion (ROM) on the hyperemic response to PLM and determine if the currently recommended protocol of moving the leg through a 90° ROM at 180°/sec provides a peak hyperemic response to PLM. 11 healthy adults underwent multiple bouts of PLM, in which either movement speed (60-240°/sec) or ROM (30-120° knee flexion) were varied. Femoral artery blood flow (Doppler Ultrasound) and mean arterial pressure (MAP; photoplethysmography) were measured throughout. Movement speed generally exhibited positive linear relationships with the hyperemic response to PLM, eliciting ~15-20% increase in hyperemia and conductance for each 30°/sec increase in speed (P < 0.05). However, increasing the movement speed above 180°/sec was physically difficult and seemingly impractical to implement. ROM exhibited curvilinear relationships (P<0.05) with hyperemia and conductance, which peaked at 90°, such that a 30° increase or decrease in ROM from 90° resulted in a 10-40% attenuation (P < 0.05) in the hyperemic response. Alterations in the balance of antegrade and retrograde flow appear to play a role in this attenuation. Movement speed and ROM have a profound impact on PLM-induced hyperemia. When using PLM to assess vascular endothelial function, it is recommended to perform the test at the traditional 180°/sec with 90° ROM, which offers a near peak hyperemic response, while maintaining test feasibility.
被动腿部运动（PLM）诱发的充血用于评估血管内皮功能。本研究旨在确定运动速度和运动范围（ROM）对PLM充血反应的影响，并确定当前推荐的以180°/秒的速度使腿部通过90°ROM进行运动的方案是否能产生PLM的最大充血反应。11名健康成年人进行了多次PLM试验，其中运动速度（60 - 240°/秒）或ROM（膝关节屈曲30 - 120°）有所变化。全程测量股动脉血流量（多普勒超声）和平均动脉压（MAP；光电容积描记法）。运动速度通常与PLM的充血反应呈正线性关系，速度每增加30°/秒，充血和血管传导率增加约15 - 20%（P < 0.05）。然而，将运动速度提高到180°/秒以上在身体上较为困难且似乎不切实际。ROM与充血和血管传导率呈曲线关系（P<0.05），在90°时达到峰值，即ROM从90°增加或减少30°会导致充血反应衰减10 - 40%（P < 0.05）。顺行和逆行血流平衡的改变似乎在这种衰减中起作用。运动速度和ROM对PLM诱发的充血有深远影响。当使用PLM评估血管内皮功能时，建议以传统的180°/秒和90°ROM进行测试，这能提供接近最大的充血反应，同时保持测试的可行性。
