Department of Exercise Sciences, Brigham Young University, Provo, UT, USA.
Program of Gerontology, Brigham Young University, Provo, UT, USA.
Physiol Rep. 2020 Aug;8(16):e14551. doi: 10.14814/phy2.14551.
While maximum blood flow influences one's maximum rate of oxygen consumption (V̇O max), with so many indices of vascular function, it is still unclear if vascular function is related to V̇O max in healthy, young adults. The purpose of this study was to determine if several common vascular tests of conduit artery and resistance artery function provide similar information about vascular function and the relationship between vascular function and V̇O max.
Twenty-two healthy adults completed multiple assessments of leg vascular function, including flow-mediated dilation (FMD), reactive hyperemia (RH), passive leg movement (PLM), and rapid onset vasodilation (ROV). V̇O max was assessed with a graded exercise test on a cycle ergometer.
Indices associated with resistance artery function (e.g., peak flow during RH, PLM, and ROV) were generally related to each other (r = 0.47-77, p < .05), while indices derived from FMD were unrelated to other tests (p < .05). Absolute V̇O max (r = 0.57-0.73, p < .05) and mass-specific V̇O max (r = 0.41-0.46, p < .05) were related to indices of resistance artery function, even when controlling for factors like body mass and sex. FMD was only related to mass-specific V̇O max after statistically controlling for baseline artery diameter (r = 0.44, p < .05).
Indices of leg resistance artery function (e.g., peak flow during RH, PLM, and ROV) relate well to each other and account for ~30% of the variance in V̇O max not accounted for by other factors, like body mass and sex. Vascular interventions should focus on improving indices of resistance artery function, not conduit artery function, when seeking to improve exercise capacity.
虽然最大血流量会影响最大摄氧量（V̇O max），但有如此多的血管功能指标，目前仍不清楚血管功能是否与健康年轻成年人的 V̇O max 相关。本研究旨在确定几种常见的主导动脉和阻力动脉功能的血管测试是否能提供关于血管功能的相似信息，以及血管功能与 V̇O max 之间的关系。
22 名健康成年人完成了多项腿部血管功能评估，包括血流介导的扩张（FMD）、反应性充血（RH）、被动腿部运动（PLM）和快速血管扩张（ROV）。V̇O max 通过在固定式自行车上进行递增负荷运动测试进行评估。
与阻力动脉功能相关的指标（例如，RH、PLM 和 ROV 期间的峰值流量）通常彼此相关（r = 0.47-77，p <.05），而源自 FMD 的指标与其他测试无关（p <.05）。绝对 V̇O max（r = 0.57-0.73，p <.05）和质量特异性 V̇O max（r = 0.41-0.46，p <.05）与阻力动脉功能的指标相关，即使在控制体重和性别等因素后也是如此。在统计学上控制基线动脉直径后（r = 0.44，p <.05），FMD 仅与质量特异性 V̇O max 相关。
腿部阻力动脉功能的指标（例如，RH、PLM 和 ROV 期间的峰值流量）彼此之间相关性良好，可解释 V̇O max 中约 30%的变异，而这些变异无法用体重和性别等其他因素来解释。在寻求提高运动能力时，血管干预应侧重于改善阻力动脉功能的指标，而不是主导动脉功能的指标。
