Department of Pediatric Dentistry, Hospital of Stomatology Hebei Medical University, Shijiazhuang, Hebei, China (mainland).
Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, Hebei, China (mainland).
Med Sci Monit. 2019 Apr 20;25:2908-2916. doi: 10.12659/MSM.913256.
BACKGROUND The aim of this research was to systematically analyze the effectiveness of calcium hydroxide compared to formocresol (FC) and camphor phenol (CP) in root canal disinfection of primary teeth. MATERIAL AND METHODS The meta-analysis was based on the participants, interventions, control, outcome (PICO) study design principle and 16 randomized-controlled clinical trials published from January 2000 to August 2018. The data heterogeneity of each study was assessed by the Q-test. The odds ratio and 95% confidence interval (CI) were calculated based on the heterogeneity results by Revman software. RESULTS Sixteen randomized-controlled clinical trials of 3047 primary teeth were included in this meta-analysis. There were significant differences of clinical effectiveness between calcium hydroxide and FC in root canal disinfection of primary teeth (OR=3.37; 95% CI range: 2.54-4.48, P<0.01) and endodontic inter-appointment emergencies (EIAE) after disinfection for 7 days (OR=0.26; 95% CI range: 0.16-0.42, P<0.01). However, there was no statistical difference of EIAE, after disinfection of primary teeth for 48 hours, between calcium hydroxide and FC (OR=0.62; 95% CI range: 0.34-1.11, P=0.11). There were significant differences of clinical effectiveness between the calcium hydroxide and CP in root canal disinfection of primary teeth (OR=5.50; 95% CI range: 3.36-8.98, P<0.01). CONCLUSIONS This meta-analysis indicated that the effectiveness of calcium hydroxide as root canal disinfectant in primary teeth was more effective than that of FC and CP.
本研究旨在系统分析氢氧化钙在儿童乳牙根管消毒中的效果，与甲醛甲酚（FC）和樟脑酚（CP）相比。
本 meta 分析基于参与者、干预措施、对照、结局（PICO）研究设计原则和 2000 年 1 月至 2018 年 8 月期间发表的 16 项随机对照临床试验。采用 Q 检验评估每项研究的数据异质性。基于 Revman 软件的异质性结果，计算比值比（OR）和 95%置信区间（CI）。
本 meta 分析共纳入 3047 颗乳牙的 16 项随机对照临床试验。在儿童乳牙根管消毒的临床疗效方面，氢氧化钙与 FC 之间存在显著差异（OR=3.37；95%CI 范围：2.54-4.48，P<0.01）和消毒后 7 天内的根管治疗期间急症（EIAE）（OR=0.26；95%CI 范围：0.16-0.42，P<0.01）。然而，在消毒后 48 小时时，EIAE 在氢氧化钙与 FC 之间无统计学差异（OR=0.62；95%CI 范围：0.34-1.11，P=0.11）。在儿童乳牙根管消毒的临床疗效方面，氢氧化钙与 CP 之间存在显著差异（OR=5.50；95%CI 范围：3.36-8.98，P<0.01）。
本 meta 分析表明，氢氧化钙作为儿童乳牙根管消毒剂的效果优于 FC 和 CP。
