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Effects of DL-alpha-difluoromethylornithine on the growth and metastasis of B16 melanoma in vivo.

作者信息

Kubota S, Ohsawa N, Takaku F

出版信息

Int J Cancer. 1987 Feb 15;39(2):244-7. doi: 10.1002/ijc.2910390220.

DOI:10.1002/ijc.2910390220
PMID:3100460
Abstract

The effects of DL-alpha-difluoromethylornithine (DFMO), a specific irreversible inhibitor of ornithine decarboxylase, on the growth of experimental mouse B16-F10 melanoma cells were investigated. DFMO (3%) in drinking water was administered to B16-F10 melanoma-bearing mice. At 24 days, B16-F10 melanomas in DFMO-fed mice weighed 75% less than those in control mice (p less than 0.001). DFMO reduced putrescine and spermidine levels in B16-F10 melanoma by 98% and 84%, respectively, and prolonged the mean survival time from 25.9 +/- 1.2 to 35.7 +/- 2.2 days (p less than 0.001). The effects of DFMO on experimental metastasis were also investigated. DFMO treatment resulted in a significant decrease in pulmonary metastasis induced by i.v. injection of B16-F10 melanoma cells.

摘要

相似文献

1
Effects of DL-alpha-difluoromethylornithine on the growth and metastasis of B16 melanoma in vivo.
Int J Cancer. 1987 Feb 15;39(2):244-7. doi: 10.1002/ijc.2910390220.
2
Antimetastatic activity of DL-alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis, in mice.多胺生物合成抑制剂DL-α-二氟甲基鸟氨酸在小鼠体内的抗转移活性
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3
Effect of inhibition of polyamine biosynthesis by DL-alpha-difluoromethylornithine on the growth and melanogenesis of B16 melanoma in vitro and in vivo.DL-α-二氟甲基鸟氨酸抑制多胺生物合成对B16黑色素瘤体外和体内生长及黑色素生成的影响。
Cancer Res. 1985 Sep;45(9):4067-70.
4
Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro.肿瘤血管生成与多胺：α-二氟甲基鸟氨酸，一种鸟氨酸脱羧酶的不可逆抑制剂，可抑制鸡胚中B16黑色素瘤诱导的血管生成以及体外血管内皮细胞的增殖。
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Effect of murine alpha-, beta-, and gamma-interferons in combination with alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis, on the tumor growth and metastasis of B16 melanoma and Lewis lung carcinoma in mice.小鼠α-、β-和γ-干扰素与多胺生物合成抑制剂α-二氟甲基鸟氨酸联合使用对小鼠B16黑色素瘤和Lewis肺癌肿瘤生长及转移的影响。
J Biol Response Mod. 1989 Apr;8(2):170-9.
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Treatment of metastatic Lewis lung carcinoma with DL-alpha-difluoromethylornithine.用DL-α-二氟甲基鸟氨酸治疗转移性Lewis肺癌。
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Potentiation by alpha-difluoromethylornithine of the activity of 3,4-dihydroxybenzylamine, a tyrosinase-dependent melanolytic agent, against B16 melanoma.α-二氟甲基鸟氨酸对3,4-二羟基苄胺（一种依赖酪氨酸酶的溶黑素剂）抗B16黑色素瘤活性的增强作用。
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Effect of polyamine depletion in vivo by DL-alpha-difluoromethylornithine on functionally distinct populations of tumoricidal effector cells in normal and tumor-bearing mice.DL-α-二氟甲基鸟氨酸在体内消耗多胺对正常和荷瘤小鼠中功能不同的杀瘤效应细胞群体的影响。
Cancer Res. 1986 Nov;46(11):5494-8.
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Effects of alpha-difluoromethylornithine on the growth of experimental Wilms' tumor and renal adenocarcinoma.α-二氟甲基鸟氨酸对实验性肾母细胞瘤和肾腺癌生长的影响。
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The effect of combination treatment with alpha-difluoromethylornithine and Corynebacterium parvum on B16 melanoma growth and tumoricidal effector cell generation in vivo.α-二氟甲基鸟氨酸与短小棒状杆菌联合治疗对体内B16黑色素瘤生长及杀瘤效应细胞生成的影响
Cancer Immunol Immunother. 1985;20(3):214-8. doi: 10.1007/BF00205579.

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DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma.DFMO/eflornithine 抑制 MYCN 下游的迁移和侵袭，并涉及神经母细胞瘤中 p27Kip1 的活性。
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Polyamine depletion induces G1 and S phase arrest in human retinoblastoma Y79 cells.多胺耗竭诱导人视网膜母细胞瘤Y79细胞的G1期和S期阻滞。
Cancer Cell Int. 2008 Jan 21;8:2. doi: 10.1186/1475-2867-8-2.
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Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells.腐胺刺激大鼠腹水肝癌细胞侵袭性的细胞内钙离子释放
Jpn J Cancer Res. 1998 Jan;89(1):67-75. doi: 10.1111/j.1349-7006.1998.tb00481.x.
7
Antiproliferative effects of interferon gamma in combination with alpha-difluoromethylornithine on human carcinoma cell cultures.γ干扰素联合α-二氟甲基鸟氨酸对人癌细胞培养物的抗增殖作用。
J Cancer Res Clin Oncol. 1994;120(12):700-6. doi: 10.1007/BF01194266.
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alpha-Difluoromethylornithine inhibits liver metastasis produced by intrasplenic injection of human tumor cells into nude mice.α-二氟甲基鸟氨酸可抑制通过将人肿瘤细胞脾内注射到裸鼠体内所产生的肝转移。
Clin Exp Metastasis. 1989 Nov-Dec;7(6):591-8. doi: 10.1007/BF01753670.
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Prevention of metastasis of intraocular melanoma in mice treated with difluoromethylornithine.用二氟甲基鸟氨酸治疗的小鼠眼内黑色素瘤转移的预防
Graefes Arch Clin Exp Ophthalmol. 1992;230(1):72-7. doi: 10.1007/BF00166766.