Department of Pharmaceutics & Biopharmaceutics, Philipps-Universität Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany.
Department of Pharmaceutics & Biopharmaceutics, Philipps-Universität Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany; Chemical Engineering Department, School of Industrial Engineering - Módulo Tecnológico Industrial (MTI), University of Vigo, Campus As Lagoas-Marcosende, 36310 Vigo, Spain.
Int J Pharm. 2019 Jun 10;564:225-236. doi: 10.1016/j.ijpharm.2019.04.048. Epub 2019 Apr 17.
At present, there is an increasing demand to improve the sustainability of surface-active compounds in dermal formulations. Biosurfactants, which are derived from living cells, are considered to be more environmentally friendly than synthetic surfactants. Thus, the use of biosurfactants is a promising strategy for the formulation of more environmentally friendly and sustainable dermal products. In this work, a biosurfactant extract (BS) obtained from corn wet-milling industry was studied for its potential use in dermal formulations. The corn derived BS possesses good surface-active properties and was found to be a suitable co-stabilizer for nanoemulsions and nanocrystals for dermal application. It also possesses antioxidative and skin protective properties and was also able to increase the dermal penetration efficacy for lipophilic actives. In dermal formulations the BS can therefore be used as co-stabilizer with antioxidative and penetration enhancing properties at the same time.
目前，人们对提高皮肤制剂中表面活性剂的可持续性的需求日益增加。生物表面活性剂是从活细胞中提取的，被认为比合成表面活性剂更环保。因此，使用生物表面活性剂是为更环保和可持续的皮肤产品制定配方的一种有前途的策略。在这项工作中，研究了从玉米湿法加工工业中获得的生物表面活性剂提取物（BS）在皮肤制剂中的潜在用途。玉米衍生的 BS 具有良好的表面活性，被发现是用于皮肤应用的纳米乳液和纳米晶体的合适共稳定剂。它还具有抗氧化和皮肤保护特性，也能够增加亲脂性活性物质的皮肤渗透效果。因此，在皮肤制剂中，BS 可以用作共稳定剂，同时具有抗氧化和增强渗透作用。
