Department of Pharmacy, Abdul Wali Khan University, Pakistan..
Department of Medical Oral and Biotechnological Sciences, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Scalo (CH), Italy.
Biotechnol Adv. 2020 Jan-Feb;38:107385. doi: 10.1016/j.biotechadv.2019.04.007. Epub 2019 Apr 18.
The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of cancers. A number of polyphenols from a wide variety of dietary sources could upregulate p53 expression in several cancer cell lines through distinct mechanisms of action. The aim of this review is to focus the significance of p53 signaling pathways and to provide molecular intuitions of dietary polyphenols in chemoprevention by monitoring p53 expression that have a prominent role in tumor suppression.
多酚的抗癌作用归因于几种信号通路，包括肿瘤抑制基因肿瘤蛋白 53(p53)。在各种类型的癌症中，内源性 p53 的表达是沉默的。许多来自各种饮食来源的多酚可以通过不同的作用机制上调几种癌细胞系中的 p53 表达。本综述的目的是关注 p53 信号通路的重要性，并通过监测在肿瘤抑制中起重要作用的 p53 表达，提供饮食多酚在化学预防中的分子见解。
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