Zinner S H, Dudley M N
J Antimicrob Chemother. 1986 Nov;18 Suppl D:49-54. doi: 10.1093/jac/18.supplement_d.49.
An in-vitro pharmacokinetic model was used to study the bactericidal activity of ciprofloxacin, alone and in combination with azlocillin. Ciprofloxacin alone produced excellent bactericidal activity against highly susceptible strains of Escherichia coli and Klebsiella pneumoniae. Against a strain of Pseudomonas aeruginosa, ciprofloxacin in clinically achievable dosing schedules produced a rapid bactericidal effect, but bacterial regrowth occurred. Azlocillin in combination with ciprofloxacin produced a rapid bacterial kill and regrowth was prevented. Further consideration of the clinical role of this combination is warranted.
采用体外药代动力学模型研究环丙沙星单独及与阿洛西林联合使用时的杀菌活性。环丙沙星单独使用时，对高度敏感的大肠杆菌和肺炎克雷伯菌菌株具有优异的杀菌活性。对于一株铜绿假单胞菌，按照临床可达到的给药方案使用环丙沙星可产生快速杀菌效果，但会出现细菌再生长。阿洛西林与环丙沙星联合使用可实现快速杀菌并防止细菌再生长。有必要进一步考虑这种联合用药的临床作用。
