Boetger C L, Ward D S
J Appl Physiol (1985). 1986 Dec;61(6):2102-7. doi: 10.1152/jappl.1986.61.6.2102.
The effect of exogenous dopamine on the development of exercise hyperpnea was studied. Using a bicycle ergometer, five subjects performed repetitive square-wave work-load testing from unloaded pedaling to 80% of each subject's estimated anaerobic threshold. The breath-by-breath ventilation (VE), CO2 production (VCO2), and O2 consumption (VO2) responses were analyzed by curve fitting a first-order exponential model. Comparisons were made between control experiments and experiments with a 3-micrograms X kg-1 X min-1 intravenous infusion of dopamine. Steady-state VE, VCO2 and VO2 were unchanged by the dopamine infusion, both during unloaded pedaling and at the heavier work load. The time constants for the increase in VE (tau VE) and VCO2 (tau CO2) were significantly (P less than 0.05) slowed (tau VE = 56.5 +/- 16.4 s for control, and tau VE = 76.4 +/- 26.6 s for dopamine; tau CO2 = 51.5 +/- 10.6 s for control, and tau CO2 = 64.8 +/- 17.4 s for dopamine) (mean +/- SD), but the time constant for VO2 (tau O2) was not significantly affected (tau O2 = 27.5 +/- 11.7 s for control, and tau O2 = 31.0 +/- 10.1 s for dopamine). We conclude that ablation of carotid body chemosensitivity with dopamine slows the transient ventilatory response to exercise while leaving the steady-state response unaffected.
研究了外源性多巴胺对运动性通气过度发展的影响。使用自行车测力计，五名受试者进行了从无负荷蹬车到每个受试者估计无氧阈值的80%的重复性方波工作量测试。通过对一阶指数模型进行曲线拟合来分析逐次呼吸的通气量（VE）、二氧化碳产生量（VCO2）和氧气消耗量（VO2）反应。在对照实验和以3微克·千克-1·分钟-1的速率静脉输注多巴胺的实验之间进行了比较。在无负荷蹬车和较重工作量期间，多巴胺输注均未改变稳态VE、VCO2和VO2。VE增加（tau VE）和VCO2增加（tau CO2）的时间常数显著（P<0.05）减慢（对照时tau VE = 56.5±16.4秒，多巴胺时tau VE = 76.4±26.6秒；对照时tau CO2 = 51.5±10.6秒，多巴胺时tau CO2 = 64.8±17.4秒）（平均值±标准差），但VO2的时间常数（tau O2）未受到显著影响（对照时tau O2 = 27.5±11.7秒，多巴胺时tau O2 = 31.0±10.1秒）。我们得出结论，多巴胺消除颈动脉体化学敏感性会减慢对运动的瞬时通气反应，而稳态反应不受影响。
