Department of Radiology, University Hospital Erlangen, Maximiliansplatz 1, 91054, Erlangen, Germany.
Department of Biomedical Imaging and Image-Guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna, Waehringer-Guertel 18-20, Vienna, Austria.
Eur J Radiol. 2019 May;114:51-56. doi: 10.1016/j.ejrad.2019.02.033. Epub 2019 Feb 28.
We performed a prospective monocentric study to inter-individually compare the diagnostic accuracy of breast MRI at 1.5 T and 3 T.
During a consecutive period of 12 months all 982 patients receiving breast MRI according to standard indications (problem solving, preoperative staging) were randomized to one 3 T or 1.5 T scanner both equipped with dedicated 16-channel breast coils. Protocols at 1.5 T and 3 T were optimized and in line with international recommendations. Due to restricted time slot availabilities, the randomization-key was defined as 1/10 (3 T/1.5 T). All examinations were read by two experts in breast MRI (>25 and 8 years of experience) who assigned a BI-RADS category per breast. Histopathological verification or long-term MRI follow-up (>24 months) served as standard of reference. Results were analyzed using cross tabulations, standard estimates of diagnostic accuracy, Chi-square test and Mann-Whitney U test (alpha = 5%).
1961 breasts were included. 1746 (89%) were imaged at 1.5 T and 215 at 3 T (11%). The 1.5 T and 3 T study cohort did not show significant differences regarding patient age (P = 0.71), results of the reference standard (P = 0.09) and indication for MRI (P = 0.53). Overall Sensitivity (94.7%), Specificity (91.4%), Accuracy (91.9%) and Negative Predictive Value (99.0%) were within the range of the literature. Pairwise comparison of Sensitivity (1,5 T/3 T: 94.1/97.9%), Specificity (91.6/%89.3%), Accuracy (92.0%/91.2%) and Negative Predictive Value (98.9%/99.3%) were without significant differences (P = 0.29-0.74).
In this prospective monocentric study, we identified comparably high diagnostic accuracy for both 1.5 T and 3 T breast MRI. Both 1.5 T and 3 T are equally suited for breast imaging.
我们进行了一项前瞻性单中心研究，旨在个体间比较 1.5T 和 3T 乳腺 MRI 的诊断准确性。
在连续 12 个月期间，所有根据标准适应证（解决问题、术前分期）接受乳腺 MRI 的 982 例患者均被随机分配至 1.5T 或 3T 扫描仪，两者均配备专用的 16 通道乳腺线圈。1.5T 和 3T 的方案进行了优化，并符合国际建议。由于时间限制，随机分配键定义为 1/10（3T/1.5T）。所有检查均由两名具有 25 年和 8 年以上乳腺 MRI 经验的专家进行阅读，每位专家均按乳腺分配 BI-RADS 类别。组织病理学验证或长期 MRI 随访（>24 个月）作为参考标准。使用交叉表、诊断准确性的标准估计、卡方检验和曼-惠特尼 U 检验（α=5%）进行结果分析。
共纳入 1961 个乳房。1746 个（89%）在 1.5T 下成像，215 个（11%）在 3T 下成像。1.5T 和 3T 研究队列在患者年龄（P=0.71）、参考标准结果（P=0.09）和 MRI 适应证（P=0.53）方面无显著差异。总体敏感性（94.7%）、特异性（91.4%）、准确性（91.9%）和阴性预测值（99.0%）均在文献范围内。敏感性（1.5T/3T：94.1%/97.9%）、特异性（91.6%/89.3%）、准确性（92.0%/91.2%）和阴性预测值（98.9%/99.3%）的两两比较无显著差异（P=0.29-0.74）。
在这项前瞻性单中心研究中，我们发现 1.5T 和 3T 乳腺 MRI 的诊断准确性均较高。1.5T 和 3T 均适用于乳腺成像。
