Chang K, Tomlinson M, Jeffrey J R, Tilton R G, Sherman W R, Ackermann K E, Berger R A, Cicero T J, Kilo C, Williamson J R
J Clin Invest. 1987 Feb;79(2):367-73. doi: 10.1172/JCI112821.
In view of the similarity of cataracts and neuropathy in galactose-fed and diabetic rats, the present experiments were undertaken to determine whether consumption of galactose-enriched diets (10, 25, or 50% by weight) also increases collagen crosslinking and permeation of vessels by 125I-albumin analogous to that observed in diabetic rats. The observations in these experiments: demonstrate that consumption of galactose-enriched diets for 3 wk selectively increases 125I-albumin permeation of the same vascular beds affected in diabetic rats and by diabetic vascular disease in humans (i.e., the aorta and vessels in the eye, kidney, sciatic nerve, and new tissue formed in the diabetic milieu); demonstrate that the susceptibility of the vasculature to aldose reductase-linked injury (increased permeability) varies greatly in different tissues; indicate that collagen solubility (crosslinking) changes in galactose-fed rats differ sharply from those in diabetic rats; and provide new evidence that consumption of galactose-enriched diets induces a hypogonadal state in male rats.
鉴于喂食半乳糖的大鼠和糖尿病大鼠中白内障与神经病变的相似性，开展了本实验，以确定食用富含半乳糖的饮食（重量比为10%、25%或50%）是否也会像在糖尿病大鼠中观察到的那样，增加胶原蛋白交联以及125I-白蛋白对血管的渗透。这些实验中的观察结果表明：食用富含半乳糖的饮食3周会选择性增加125I-白蛋白对糖尿病大鼠以及人类糖尿病血管疾病所影响的相同血管床（即主动脉以及眼、肾、坐骨神经中的血管和在糖尿病环境中形成的新组织）的渗透；表明脉管系统对醛糖还原酶相关损伤（通透性增加）的易感性在不同组织中差异很大；表明喂食半乳糖的大鼠中胶原蛋白溶解度（交联）的变化与糖尿病大鼠中的变化截然不同；并提供了新的证据，证明食用富含半乳糖的饮食会导致雄性大鼠性腺功能减退。
