筛查脐血中的先天性缺铁症。
Screening umbilical cord blood for congenital Iron deficiency.
机构信息
Department of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA.
Department of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA; Women and Newborn's Clinical Program, Intermountain Healthcare, Murray, UT, USA; Department of Pediatrics, Division of Hematology/Oncology, University of Utah Health, Salt Lake City, UT, USA.
出版信息
Blood Cells Mol Dis. 2019 Jul;77:95-100. doi: 10.1016/j.bcmd.2019.04.005. Epub 2019 Apr 8.
OBJECTIVES
Small for gestational age infants (SGA), infants of diabetic mothers (IDM), and very low birth weight infants (VLBW) are at risk for congenital iron deficiency. We evaluated the iron status of SGA, IDM, and VLBW neonates at birth and sought mechanistic explanations in those with iron deficiency.
METHODS
This was a prospective study. If congenital iron deficiency was present, maternal iron studies were obtained. When neonates were two weeks old, their iron status was reevaluated.
RESULTS
Sixteen of 180 neonates screened were iron deficient at birth. The Body Mass Index of the 16 mothers was high. These mothers often had mild iron deficiency and measurable hepcidin levels. Two weeks after birth, neonates had improved iron measurements.
CONCLUSIONS
Among SGA, IDM, and VLBW neonates, maternal obesity is a risk factor for congenital iron deficiency. We speculate that elevated hepcidin levels in obese pregnant women impede iron absorption and interfere with transplacental iron transfer.
目的
小于胎龄儿（SGA）、糖尿病母亲婴儿（IDM）和极低出生体重儿（VLBW）存在先天性铁缺乏的风险。我们评估了 SGA、IDM 和 VLBW 新生儿出生时的铁状况，并在铁缺乏的新生儿中寻找其发生的机制。
方法
这是一项前瞻性研究。如果存在先天性铁缺乏，将进行母体铁研究。当新生儿两周大时，重新评估其铁状况。
结果
在筛查的 180 名新生儿中，有 16 名在出生时铁缺乏。16 名母亲的体重指数较高。这些母亲经常有轻度缺铁和可测量的铁调素水平。出生两周后，新生儿的铁测量值有所改善。
结论
在 SGA、IDM 和 VLBW 新生儿中，母亲肥胖是先天性铁缺乏的一个危险因素。我们推测，肥胖孕妇的铁调素水平升高会阻碍铁的吸收，并干扰胎盘铁转运。
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