Giuntoli Lorenzo, Dalmastri Vittorio, Cilloni Nicola, Orsi Claudio, Stalteri Lucia, Demelas Valentina, Giuliani Giovanni, Gordini Giovanni, De Ponti Fabrizio, La Manna Gaetano
1 Department of Emergency-Urgency Medicine, Intensive Care Unit, Maggiore Hospital, Bologna, Italy.
2 Nephrology, Dialysis and Transplantation Unit, Azienda Ospedaliera-Universitaria di Bologna, Bologna, Italy.
Int J Artif Organs. 2019 Sep;42(9):516-520. doi: 10.1177/0391398819837686. Epub 2019 Apr 22.
Quetiapine overdose, although rare, is mainly linked with tachycardia, QTc-interval prolongation, somnolence, coma, hyperglycemia, and eventually hepatotoxicity and myocarditis. Extracorporeal techniques for quetiapine removal might be helpful, but only a few cases are reported in the literature. We here describe the case of a 27-year-old healthy woman, admitted to our Intensive Care Unit after voluntary quetiapine intake and successfully treated with CytoSorb hemoperfusion in combination with continuous renal replacement therapy (CRRT), in order to accelerate quetiapine elimination. This is the first published experience about the potential application of hemoadsorption therapies, as CytoSorb sorbent, in large overdoses of quetiapine and this approach might be feasible to rapidly remove the substance from blood, stabilizing the patient condition.
喹硫平过量服用虽较为罕见，但主要与心动过速、QTc间期延长、嗜睡、昏迷、高血糖症相关，最终可导致肝毒性和心肌炎。采用体外技术清除喹硫平可能会有所帮助，但文献中仅报道了少数病例。我们在此描述一名27岁健康女性的病例，该患者在自愿服用喹硫平后入住我们的重症监护病房，并成功接受了CytoSorb血液灌流联合连续性肾脏替代疗法（CRRT）治疗，以加速喹硫平的清除。这是关于血液吸附疗法（如CytoSorb吸附剂）在大剂量喹硫平过量服用中潜在应用的首次发表经验，这种方法可能有助于快速从血液中清除该物质，稳定患者病情。
