Starinsky-Elbaz Sigal, Ariel Tal, Issan Yossi
DNA Database Laboratory, Division of Identification and Forensic Science (DIFS), Israel Police, National H.Q., Jerusalem 91906, Israel.
DNA Database Laboratory, Division of Identification and Forensic Science (DIFS), Israel Police, National H.Q., Jerusalem 91906, Israel.
Forensic Sci Int. 2019 Jul;300:e20-e23. doi: 10.1016/j.forsciint.2019.03.045. Epub 2019 Apr 3.
DNA-based analysis is an important tool for the identification of unidentified human remains (UHR). Comparing DNA of UHR with DNA profiles of missing persons' relatives may provide genetic data leading to identification. In most cases, DNA profiles of missing persons are not available and therefore, the identification process must be based on kinship analysis. UHR were found buried in Southern Israel in 2016. Kinship analysis indicated potential family links to members of a Bedouin family. The Joint Pedigree Likelihood Ratio (JPLR) was lower than the familial database threshold and the match could easily have been missed due to its low value (245). A few factors led to expanded analysis, and the addition of more family members (from the forensic database), as well as the exclusion of half-sister, radically increased the JPLR value (4.94 × 10). This case demonstrates the crucial importance of examining the metadata and analyzing the STRs regarding family links in cases of low JPLR, as well as the need to re-calculate the JPLR individually for each family member in the pedigree versus the UHR, and to increase the number of family members uploaded into the pedigree.
基于DNA的分析是识别身份不明人类遗骸（UHR）的重要工具。将UHR的DNA与失踪人员亲属的DNA图谱进行比较，可能会提供有助于身份识别的遗传数据。在大多数情况下，失踪人员的DNA图谱不可用，因此，身份识别过程必须基于亲缘关系分析。2016年，在以色列南部发现了身份不明的人类遗骸。亲缘关系分析表明，这些遗骸与一个贝都因家庭的成员可能存在家族联系。联合谱系似然比（JPLR）低于家族数据库阈值，由于其值较低（245），很容易错过匹配。一些因素导致了分析范围的扩大，增加了更多家庭成员（来自法医数据库），以及排除同父异母的妹妹，极大地提高了JPLR值（4.94×10）。该案例表明，在JPLR值较低的情况下，检查元数据并分析与家族联系相关的短串联重复序列（STR）至关重要，同时也表明有必要针对谱系中的每个家庭成员与UHR单独重新计算JPLR，并增加上传到谱系中的家庭成员数量。
