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心脏瓣膜手术后早期个体化强化随访对计划性心脏再入院和全因死亡率的影响。

Effect of early, individualised and intensified follow-up after open heart valve surgery on unplanned cardiac hospital readmissions and all-cause mortality.

机构信息

Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Odense, Denmark; OPEN, Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark; Department of Cardiology, Odense University Hospital, Odense, Denmark.

出版信息

Int J Cardiol. 2019 Aug 15;289:30-36. doi: 10.1016/j.ijcard.2019.02.056. Epub 2019 Apr 11.

Abstract

BACKGROUND

Unplanned readmissions after heart valve surgery are common, and constitute a significant burden for the patient and the health care system. The objective was to investigate the effect of individualised follow-up after open heart valve surgery on a composite endpoint of first unplanned cardiac hospital readmission or all-cause mortality within 180 days of discharge.

METHODS

The study is a prospective cohort study comparing the composite endpoint in patients undergoing early, individualised and intensified follow-up after heart valve surgery with a propensity matched historical control group. A total of 308 consecutive patients were enrolled in the prospective cohort study, 980 consecutive patients comprised the control group. The propensity matched group consisted of n = 300 (intervention) and n = 580 (controls). Time to first event was analysed using uni- and multivariable Cox proportional hazard analysis. Kaplan-Meier survival curves were constructed to assess the probability of survival without readmission.

RESULTS

After 180 days, the proportion of patients experiencing the composite endpoint was significantly lower in the intervention group compared with the controls for the overall, unmatched population (23% vs. 38%; HR 0.55; 95% CI, 0.42 to 0.73; P < 0.001). The effect did not change in the propensity matched population (HR 0.57; 95% CI 0.43;0.75, P < 0.001). The difference was related to reduction in readmission rates, whereas death rates were similar in intervention and control group (1.6% vs. 1.8%).

CONCLUSION

An intervention consisting of early, individualised and intensified follow-up after open heart valve surgery reduced the risk of a composite endpoint of first, unplanned cardiac hospital readmission or all-cause mortality within 180 days.

摘要

背景

心脏瓣膜手术后的非计划性再入院很常见,这给患者和医疗保健系统带来了巨大负担。本研究旨在探究心脏瓣膜手术后个体化随访对出院后 180 天内首次非计划性心脏住院再入院或全因死亡率复合终点的影响。

方法

本研究为前瞻性队列研究,比较了心脏瓣膜手术后早期个体化强化随访患者的复合终点与倾向性匹配历史对照组。前瞻性队列研究共纳入 308 例连续患者,对照组纳入 980 例连续患者。倾向性匹配组包括 n=300(干预组)和 n=580(对照组)。使用单变量和多变量 Cox 比例风险分析评估首次事件时间。绘制 Kaplan-Meier 生存曲线以评估无再入院生存率。

结果

180 天后,与对照组相比,干预组总体、未匹配人群中复合终点的患者比例显著降低(23%比 38%;HR 0.55;95%CI 0.42 至 0.73;P<0.001)。在倾向性匹配人群中,效果没有改变(HR 0.57;95%CI 0.43 至 0.75;P<0.001)。这种差异与降低再入院率有关,而干预组和对照组的死亡率相似(1.6%比 1.8%)。

结论

心脏瓣膜手术后早期个体化强化随访可降低出院后 180 天内首次非计划性心脏住院再入院或全因死亡率的复合终点风险。

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