Department of Technological Innovations, INAIL, Rome, Italy.
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
J Alzheimers Dis. 2019;68(4):1371-1390. doi: 10.3233/JAD-181266.
This paper presents an overview of the literature studies on the sources of ultrafine particles (UFPs), nanomaterials (NMs), and nanoparticles (NPs) occurring in indoor (occupational and residential) and outdoor environments. Information on the relevant emission factors, particle concentrations, size, and compositions is provided, and health relevance of UFPs and NPs is discussed. Particular attention is focused on the fraction of particles that upon inhalation deposit on the olfactory bulb, because these particles can possibly translocate to brain and their possible role in neurodegenerative diseases is an important issue emerging in the recent literature.
本文综述了室内（职业和住宅）和室外环境中产生的超细颗粒（UFPs）、纳米材料（NMs）和纳米颗粒（NPs）的文献研究。提供了有关相关排放因子、颗粒浓度、大小和成分的信息，并讨论了 UFPs 和 NPs 的健康相关性。特别关注的是吸入后沉积在嗅球上的颗粒部分，因为这些颗粒可能会转移到大脑中，它们在神经退行性疾病中的可能作用是最近文献中出现的一个重要问题。
