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CrossTalk opposing view: Heart rate variability as a measure of cardiac autonomic responsiveness is fundamentally flawed.

作者信息

Boyett Mark, Wang Yanwen, D'Souza Alicia

机构信息

Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.

出版信息

J Physiol. 2019 May;597(10):2599-2601. doi: 10.1113/JP277501. Epub 2019 Apr 21.

DOI:10.1113/JP277501
PMID:31006856
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6826226/
Abstract
摘要

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CrossTalk opposing view: Heart rate variability as a measure of cardiac autonomic responsiveness is fundamentally flawed.相互矛盾的观点：将心率变异性作为心脏自主反应性的一种测量方法从根本上说是有缺陷的。
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Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia.靶向miR-423-5p可逆转运动训练诱导的HCN4通道重塑和窦性心动过缓。
Circ Res. 2017 Oct 13;121(9):1058-1068. doi: 10.1161/CIRCRESAHA.117.311607. Epub 2017 Aug 17.
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Cardiac Autonomic Responses during Exercise and Post-exercise Recovery Using Heart Rate Variability and Systolic Time Intervals-A Review.利用心率变异性和收缩期时间间期评估运动及运动后恢复期间的心脏自主神经反应——综述
Front Physiol. 2017 May 29;8:301. doi: 10.3389/fphys.2017.00301. eCollection 2017.
3
A novel 'splice site' HCN4 Gene mutation, c.1737+1 G>T, causes familial bradycardia, reduced heart rate response, impaired chronotropic competence and increased short-term heart rate variability.一种新的“HCN4基因剪接位点”突变，c.1737+1 G>T，导致家族性心动过缓、心率反应降低、变时性功能受损及短期心率变异性增加。
Int J Cardiol. 2017 Aug 15;241:364-372. doi: 10.1016/j.ijcard.2017.04.058. Epub 2017 Apr 20.
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Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate.心率变异性与心率之间未被充分认识但重要的关系的生物物理特征
Hypertension. 2014 Dec;64(6):1334-43. doi: 10.1161/HYPERTENSIONAHA.114.03782. Epub 2014 Sep 15.
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Exercise training reduces resting heart rate via downregulation of the funny channel HCN4.运动训练通过下调超极化激活的环核苷酸门控阳离子通道4（HCN4）来降低静息心率。
Nat Commun. 2014 May 13;5:3775. doi: 10.1038/ncomms4775.
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The role of the funny current in pacemaker activity.有趣电流在起搏器活动中的作用。
Circ Res. 2010 Feb 19;106(3):434-46. doi: 10.1161/CIRCRESAHA.109.208041.
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Cardiovasc Res. 2001 Jun;50(3):434-42. doi: 10.1016/s0008-6363(01)00240-1.
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