Department of Dermatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Department of Dermatology, University Hospitals KU Leuven, Leuven, Belgium.
Contact Dermatitis. 2019 Oct;81(4):262-265. doi: 10.1111/cod.13295. Epub 2019 May 31.
Allergic contact dermatitis caused by leather is common, and several responsible allergens, such as tanning agents, glues, mercaptobenzothiazole derivatives, and dyes, but also antimicrobials and antifungals, are involved.
Three female patients were referred to the Departments of Dermatology in a Belgian university hospital following skin reactions caused by leather products (shoes, belt, and car seats). They were patch tested with the European baseline series and samples of suspected leather products, and additionally with 2-(thiocyanomethylthio)benzothiazole (TCMTB), an antifungal agent previously reported to be a contact allergen in footwear. Chromatographic analyses of samples of all the leather materials tested were performed at the Department of Occupational and Environmental Dermatology in Malmö, Sweden.
The patients reacting to the leather samples were shown to be sensitized to TCMTB, the presence of which could be confirmed by chemical analyses of samples obtained from the patients.
Patch tests with TCMTB should be considered in patients with contact dermatitis caused by leather items.
由皮革引起的过敏性接触性皮炎很常见，涉及几种过敏原，如鞣制剂、胶水、巯基苯并噻唑衍生物和染料，还有抗菌剂和抗真菌剂。
三名女性患者因皮革制品（鞋、皮带和汽车座椅）引起的皮肤反应而被转诊至比利时一所大学医院的皮肤科。他们接受了欧洲基础系列和疑似皮革制品样本的斑贴试验，以及此前报道的一种在鞋类中作为接触过敏原的抗真菌剂 2-（硫氰基甲基硫代）苯并噻唑（TCMTB）的斑贴试验。在瑞典马尔默职业和环境皮肤病学系对所有测试的皮革材料样本进行了色谱分析。
对皮革样本产生反应的患者被证实对 TCMTB 敏感，通过对患者样本进行化学分析可以确认 TCMTB 的存在。
对于由皮革制品引起的接触性皮炎患者，应考虑进行 TCMTB 斑贴试验。
