Kato K, Watanabe R, Ito E, Sakamoto T, Morishima M, Hoshino K, Tanaka M, Tadokoro N
Nihon Sanka Fujinka Gakkai Zasshi. 1986 Dec;38(12):2241-50.
The difference between prolactin (PRL) basal levels on separate days in the 6 normoprolactinemic women--one case with an anovular cycle and 5 cases with 1 degree amenorrhea--among 14 normoprolactinemic women with ovulatory disturbances, showed significantly variation over 13 ng/ml within the normal range of the PRL basal level. PRL pulse frequencies of the same cases from 0900 h. to 1400 h. increased slightly compared with follicular phase. At the same time, the PRL pulse amplitudes were significantly higher than in the follicular phase but significantly lower than the PRL pulse amplitudes in hyperprolactinemic women. The net increase in PRL to TRH in the 6 cases was over 100 ng/ml. When the PRL net increase to TRH was over 100 ng/ml in normoprolactinemic women with ovulatory disturbances, the case is regarded as latent hyperprolactinemia. And 1 or 2 may be latent hyperprolactinemic syndrome. The LH/FSH basal level and delta LH/delta FSH to LH-RH before administration of bromocriptine increased in these cases compared with the follicular phase. During the administration of bromocriptine, the ratios decreased and approached the ratio in the follicular phase. The effect of clomid was improved by increased E2 in these cases.
14例排卵功能障碍的正常催乳素血症女性中，6例正常催乳素血症女性（1例无排卵周期，5例Ⅰ度闭经）不同日期的催乳素（PRL）基础水平差异显示，在PRL基础水平正常范围内有超过13 ng/ml的显著变化。同一病例从09:00至14:00的PRL脉冲频率与卵泡期相比略有增加。同时，PRL脉冲幅度显著高于卵泡期，但显著低于高催乳素血症女性的PRL脉冲幅度。6例患者对促甲状腺激素释放激素（TRH）的PRL净增量超过100 ng/ml。排卵功能障碍的正常催乳素血症女性中，当对TRH的PRL净增量超过100 ng/ml时，该病例被视为潜在性高催乳素血症。其中1或2例可能为潜在性高催乳素血症综合征。与卵泡期相比，这些病例在服用溴隐亭前促黄体生成素（LH）/促卵泡生成素（FSH）基础水平及LH-RH刺激后的△LH/△FSH升高。在服用溴隐亭期间，这些比值下降并接近卵泡期的比值。这些病例中，克罗米酚的效果因雌二醇（E2）升高而改善。
