Ishimaru T, Mori H, Koh K, Imamichi S, Morisaki M, Kohno A, Yoshida K, Imamura S, Yamabe T
Nihon Sanka Fujinka Gakkai Zasshi. 1980 Oct;32(10):1583-90.
The ovulation-inducing effect of bromocriptine (CB-154) and the underlying mechanism in the management of anovulatory infertility with normoprolactinemia were investigated. Thirty-seven normoprolactinemic women (anovulatory cycle, 11 cases; 1st grade amenorrhea, 18; and 2nd grade amenorrhea 8) with anovulia showing plasma prolactin levels of less than 25 ng/ml were give CB-154 daily in doses of 2.5 mh from the second day of menstruation or withdrawal bleeding (1) to assess the ovulatory induction rate, (2) to determine the serum PRL, LH, FSH and E2 levels before and during the drug administration, (3) to measure the serum PRL concentration by TRH test prior to CB-154 medication and (4) to assess size heterogeneity of serum PRL with the use of lyophilization.
(1) Ovulation occurred in 21 of the 37 patients, of a total of 42 menstrual cycles studied, 33 were ovulatory, indicating a high rate of repeated success. (2) There was a significant decrease of serum PRL following administration of CB-154, and the finding was the same in the group of women with successful ovulatory induction. Serum LH, FSH and E2 levels did not show any significant change following CB-154 therapy. (3) Prl concentrations were suppressed more in cases of unsuccessful induction than those in successful induction. (4) PRL responses to TRH tended to be lower in cases of successful induction than those in unsuccessful cases. (5) The Little PRL content ratio decreased after administration of CB-154, and this data have suggested that not only the problem of immunologically measured serum PRL levels but the qualitative problems also bear relations to the effect of this hormone on the endocrinological environment.
研究了溴隐亭（CB - 154）的促排卵作用及其在治疗伴有正常催乳素血症的无排卵性不孕症中的潜在机制。37名催乳素水平正常的女性（无排卵周期11例、Ⅰ度闭经18例、Ⅱ度闭经8例），血浆催乳素水平低于25 ng/ml且无排卵，从月经周期的第二天或撤药性出血的第二天起，每日给予2.5 mg的CB - 154，以评估：（1）促排卵率；（2）确定给药前及给药期间血清催乳素（PRL）、促黄体生成素（LH）、促卵泡生成素（FSH）和雌二醇（E2）水平；（3）在服用CB - 154之前通过促甲状腺激素释放激素（TRH）试验测量血清PRL浓度；（4）使用冻干法评估血清PRL的大小异质性。
（1）37例患者中有21例排卵，在总共研究的42个月经周期中，33个周期有排卵，表明重复成功率很高。（2）服用CB - 154后血清PRL显著下降，在成功诱导排卵的女性组中也是如此。CB - 154治疗后血清LH、FSH和E2水平未显示任何显著变化。（3）诱导失败的病例中PRL浓度比诱导成功的病例抑制得更多。（4）成功诱导的病例中PRL对TRH的反应往往低于失败的病例。（5）服用CB - 154后小PRL含量比例下降，该数据表明不仅免疫测定的血清PRL水平问题，而且质量问题也与该激素对内分泌环境的影响有关。
