Kubanov Alexey, Gallyamova Yuliya, Kravchenko Anzhela
Russian Medical Academy of Continuous Professional Education, Ministry of Healthcare of the Russian Federation, Moscow, Russia.
Dermatol Reports. 2019 Mar 28;11(1):7675. doi: 10.4081/dr.2019.7675. eCollection 2019 Jan 23.
The article analyzes the clinical picture and course of rosacea in patients with mites. It presents the advantages of using the method of confocal laser scanning microscopy over the method of light microscopy of facial skin scrapes. The aimes were to study the influence of mites on the clinical picture and course of rosacea; to compare laboratory and instrumental diagnostic methods for detecting mites; to evaluate the effectiveness of external therapy aimed at eliminating mites. 212 people were examined. The study included healthy patients, patients with a diagnosis of rosacea with the presence and absence of . The presence of mites was confirmed by two methods of study (light microscopy of skin scrapes and confocal laser scanning microscopy). mites promote the development of acute-inflammatory morphological elements, increase the duration of the condition (more than 5 years, P<0.01) and the probability of recurrence (from 1 to 3 relapses in 39.5% of patients, P<0.05), resulting in a decrease in the quality of life of patients (dermatology life quality index is 12.5±4.5, P<0.05). Antiparasitic drug ivermectin, in the form of an external form, at a concentration of 1% has a high therapeutic efficacy (in 93.3% of cases). folliculorum shows signs of parasitism, while folliculorum brevis is a saprophyte. The severity of the condition does not depend on the quantitative load of the mites in the scrape. As an antiparasitic drug, it is recommended to use 1% ivertmectin.
本文分析了有螨虫的酒渣鼻患者的临床表现和病程。介绍了共聚焦激光扫描显微镜检查法相较于面部皮肤刮片光学显微镜检查法的优势。目的是研究螨虫对酒渣鼻临床表现和病程的影响;比较检测螨虫的实验室和仪器诊断方法;评估旨在消除螨虫的外用疗法的有效性。对212人进行了检查。该研究包括健康患者、诊断为酒渣鼻且有或无[此处原文缺失相关内容]的患者。通过两种研究方法(皮肤刮片光学显微镜检查和共聚焦激光扫描显微镜检查)确认了螨虫的存在。螨虫会促进急性炎症形态学要素的发展,增加病情持续时间(超过5年,P<0.01)和复发概率(39.5%的患者有1至3次复发,P<0.05),导致患者生活质量下降(皮肤病生活质量指数为12.5±4.5,P<0.05)。外用1%浓度的抗寄生虫药物伊维菌素具有较高的治疗效果(93.3%的病例有效)。毛囊蠕形螨显示出寄生迹象,而短毛囊蠕形螨是腐生菌。病情的严重程度并不取决于刮片中螨虫的数量负荷。作为抗寄生虫药物,建议使用1%的伊维菌素。