INSERM U987, Ambroise Paré Hospital, APHP, Boulogne-Billancourt, France.
Université Versailles Saint Quentin en Yvelines, Versailles, France.
Pain. 2019 May;160 Suppl 1:S23-S28. doi: 10.1097/j.pain.0000000000001522.
The traditional translational approach in neuropathic pain research has mainly consisted to date in translating basic findings from animal models of nerve injury to the clinic. Because of the difficulty to extrapolate mechanisms from animals to humans, an inverse translational approach ("top-down") has been advocated and contributed to the development of therapy. In particular, a number of treatments such as neurostimulation techniques have been initially assessed in patients and then translated to animal models for further investigation of their mechanisms. Therapeutic approaches based on an in-depth assessment of sensory phenotypes, suggestive of mechanisms, have also been implemented. The biggest trend in recent translational research is to investigate mechanisms or predict therapeutic response in patients by integrating multimodal approaches. The present narrative review emphasizes these various aspects of translational research in neuropathic pain.
目前，神经病理性疼痛研究中的传统转化方法主要是将神经损伤动物模型的基础研究发现转化到临床。由于从动物推断机制到人类存在困难，因此提倡采用反向转化方法（“自上而下”），并推动了治疗方法的发展。特别是，一些治疗方法，如神经刺激技术，最初在患者中进行评估，然后在动物模型中进行进一步研究，以探讨其机制。基于对提示机制的感觉表型进行深入评估的治疗方法也已实施。最近转化研究中最大的趋势是通过整合多模态方法来研究患者的机制或预测治疗反应。本综述强调了神经病理性疼痛转化研究的这些各个方面。
