Rao L N, Ammirati M, Murthy S M, Goldschmidt R A, Ciric I S, Scanlon E F
Lasers Surg Med. 1986;6(5):477-84. doi: 10.1002/lsm.1900060512.
The milliwatt carbon dioxide laser was used to induce focal lesions and to perform wedge resections in the livers of 75 strain A mice. The procedures were feasible and well tolerated by the mice, with only one postoperative death in the wedge resection group in an early experiment. The hepatic lesions produced by the laser were characterized histologically by an inner area of vaporization, an intermediate area of coagulation necrosis, and an outer rim of cells with variable damage. The lesions healed by fibroblastic proliferation and scar formation with no hepatocytic contribution. The small vessel and bile ductule sealing effect of CO2 laser, together with the sound healing of laser-induced wounds, highlights the usefulness of this modality in liver surgery in general, and suggests its particular application in the treatment of liver trauma and a variety of hepatic focal lesions, neoplastic or otherwise.
使用毫瓦级二氧化碳激光在75只A品系小鼠的肝脏中诱导局灶性病变并进行楔形切除术。这些操作是可行的，小鼠耐受性良好，在早期实验的楔形切除组中仅有1只小鼠术后死亡。激光造成的肝脏病变在组织学上的特征为内部汽化区域、中间凝固性坏死区域以及外部有不同程度损伤的细胞边缘。病变通过成纤维细胞增殖和瘢痕形成愈合，无肝细胞参与。二氧化碳激光对小血管和胆小管的封闭作用，以及激光诱导伤口的良好愈合，突出了这种方式在一般肝脏手术中的实用性，并表明其在肝外伤和各种肝脏局灶性病变（无论是否为肿瘤性病变）治疗中的特殊应用价值。
