Clotaire Daguia Zambe John, Wei Yudong, Yu Xiuwei, Ousman Tamgue, Hua Jinlian
College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China; and Laboratoire des sciences Agronomiques et Biologiques pour le Développement (LASBAD), Faculty of Science, University of Bangui, Bangui, 999111, Central Africa.
College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Reprod Fertil Dev. 2019 Jul;31(8):1315-1320. doi: 10.1071/RD18252.
Promyelocytic leukaemia zinc finger (Plzf), also known as zinc finger and BTB domain containing 16 (ZBTB16) or zinc-finger protein 145 (ZFP145), is a critical zinc finger protein of male germline stem cells (mGSCs). Multiple lines of evidence indicate that Plzf has a central role in the development, differentiation and maintenance of many stem cells, including mGSCs, and Plzf has been validated as an essential transcription factor for mammalian testis development and spermatogenesis. This review summarises current literature focusing on the significance of Plzf in maintaining and regulating self-renewal and differentiation of mGSCs, especially goat mGSCs. The review summarises evidence of the specificity of Plzf expression in germ cell development stage, the known functions of Plzf and the microRNA-mediated mechanisms that control Plzf expression in mGSCs.
早幼粒细胞白血病锌指蛋白（Plzf），也被称为含锌指和BTB结构域蛋白16（ZBTB16）或锌指蛋白145（ZFP145），是雄性生殖系干细胞（mGSCs）的一种关键锌指蛋白。多项证据表明，Plzf在包括mGSCs在内的多种干细胞的发育、分化和维持过程中发挥着核心作用，并且Plzf已被确认为哺乳动物睾丸发育和精子发生的必需转录因子。本综述总结了当前的文献，重点关注Plzf在维持和调节mGSCs，尤其是山羊mGSCs的自我更新和分化方面的重要性。该综述总结了Plzf在生殖细胞发育阶段表达特异性的证据、Plzf的已知功能以及控制mGSCs中Plzf表达的microRNA介导机制。
