Epidemiology and Statistics Group, Research Center, A.C Camargo Cancer Center, São Paulo, Brazil.
Epidemiology and Statistics Group, Research Center, A.C Camargo Cancer Center, São Paulo, Brazil.
Cancer Epidemiol. 2019 Jun;60:141-148. doi: 10.1016/j.canep.2019.04.003. Epub 2019 Apr 19.
To describe the prevalence of Helicobacter pylori (H. pylori) infection in Latin Americaand the Caribbean (LAC), through systematic review and meta-analysis by age groups and gender.
Systematic review and meta-analysis of the population-based observational epidemiological studies carried out in LAC, focused on the prevalence of H. pylori and published until March, 2018. The databases utilized in the search were MEDLINE, SCIELO andPUBMED. The prevalence described in the meta-analysis and 95% confidence intervals were estimated by the random effects model, and weighted by the size of the study.
The 22 selected studies were carried out in 14 countries of LAC, and included 24,178 individuals. The studies were conducted between 1987 and 2012, and all were representative of at least one city. The prevalence of H. pylori infection was 57.57% (CI95%:50.43;64.72) for all ages; in children and adolescents the prevalence was 48.36% (CI95%:38.03;58.70) and in adults 69.26%(CI95%:64.54;76.99). No differences were observed regarding sex.
Prevalence of H. pylori infection in LAC is high for all age groups. These data reinforce the necessity of actions towards the prevention and treatment of H. pylori infection for all age groups. Treating H pylori infection in young ages probably will reduce gastric cancer incidence in the future.
通过按年龄组和性别进行系统评价和荟萃分析，描述拉丁美洲和加勒比地区（LAC）的幽门螺杆菌（H. pylori）感染流行情况。
对在 LAC 进行的基于人群的观察性流行病学研究进行系统评价和荟萃分析，重点关注 H. pylori 的流行情况，并于 2018 年 3 月之前发表。在搜索中使用的数据库是 MEDLINE、SCIELO 和 PUBMED。荟萃分析中描述的流行率和 95%置信区间是通过随机效应模型估计的，并按研究规模加权。
选择的 22 项研究在 LAC 的 14 个国家进行，共纳入 24178 人。这些研究于 1987 年至 2012 年进行，均代表至少一个城市。所有年龄段的 H. pylori 感染流行率为 57.57%（95%CI95%：50.43；64.72）；儿童和青少年的流行率为 48.36%（95%CI95%：38.03；58.70），成年人的流行率为 69.26%（95%CI95%：64.54；76.99）。性别方面无差异。
LAC 所有年龄段的 H. pylori 感染流行率均较高。这些数据加强了针对所有年龄段的 H. pylori 感染预防和治疗的必要性。在年轻时治疗 H. pylori 感染可能会降低未来胃癌的发病率。
