Icahn School of Medicine at Mount Sinai, New York, New York (A.S.).
Yale School of Medicine, Yale School of Public Health, New Haven, Connecticut (H.A.).
Ann Intern Med. 2019 Jul 2;171(1):51-57. doi: 10.7326/M19-0961. Epub 2019 Apr 23.
On 30 and 31 October 2018, the National Institutes of Health convened the Pathways to Prevention (P2P) Workshop: Appropriate Use of Drug Therapies for Osteoporotic Fracture Prevention to assess the available evidence on long-term (>3 years) use of drug therapies to prevent osteoporotic fractures and identify research gaps and needs for advancing the field. The workshop was cosponsored by the NIH Office of Disease Prevention (ODP), National Institute of Arthritis and Musculoskeletal and Skin Diseases, and National Institute on Aging. A multidisciplinary working group developed the agenda, and an Evidence-based Practice Center prepared an evidence report through a contract with the Agency for Healthcare Research and Quality to facilitate the discussion. During the 1.5-day workshop, invited experts discussed the body of evidence and attendees had the opportunity to comment during open discussions. After data from the evidence report, expert presentations, and public comments were weighed, an unbiased independent panel prepared a draft report that was posted on the ODP Web site for 5 weeks for public comment. This final report summarizes the panel's findings and recommendations. Current gaps in knowledge are highlighted, and a set of recommendations for new, strengthened research to better inform the long-term use of osteoporotic drug therapies is delineated.
2018 年 10 月 30 日和 31 日，美国国立卫生研究院召开了预防途径（P2P）研讨会：适当使用药物治疗骨质疏松性骨折预防，以评估长期（> 3 年）使用药物治疗预防骨质疏松性骨折的现有证据，并确定该领域的研究差距和需求。该研讨会由 NIH 疾病预防办公室（ODP）、国家关节炎和肌肉骨骼及皮肤病研究所和国家老龄化研究所共同主办。一个多学科工作组制定了议程，一个循证实践中心通过与医疗保健研究和质量局签订合同编写了一份证据报告，以促进讨论。在为期 1.5 天的研讨会上，受邀专家讨论了证据主体，与会者有机会在公开讨论中发表评论。在权衡证据报告、专家演讲和公开意见的数据后，一个无偏见的独立小组编写了一份报告草案，并在 ODP 网站上发布了 5 周供公众评论。本最终报告总结了小组的调查结果和建议。突出了当前知识差距，并提出了一系列新的、强化的研究建议，以更好地为骨质疏松性药物治疗的长期使用提供信息。
