Ghonimi Nesma A M, Mahdy Mohamed E, Abdel Salam Osama A
Department of Neurology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Department of Neurology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
J Stroke Cerebrovasc Dis. 2019 Jul;28(7):1911-1917. doi: 10.1016/j.jstrokecerebrovasdis.2019.03.053. Epub 2019 Apr 20.
Oxidative stress after ischemic stroke contributes to neuronal cell injury. We tried to demonstrate an association between total antioxidant capacity (TAC) levels and outcomes after acute ischemic stroke (AIS).
We enrolled 60 patients (36 females and 24 males) who were admitted to our hospital due to AIS, in addition to 30 age and sex-matched healthy controls. TAC levels were measured on day 1 of stroke onset, the relationships between TAC levels, stroke subtypes, and clinical outcomes based on the National Institutes of Health Stroke Scale and modified Rankin scale upon discharge were evaluated.
TAC levels were significantly lower in AIS patients than control (P < .001) being much lower in patients with large-vessel cerebral infarction than in those with small-vessel infarction. We investigated whether TAC concentrations reflected the severity and outcome of ischemic stroke and we found a significantly lower concentration of TAC in the poor outcome group than in the good outcome group (P < .001).
Our findings suggested that the biochemical changes related to TAC and oxidative stress may be considered a marker of ischemic brain injury and clinical outcome of ischemic stroke.
缺血性中风后的氧化应激会导致神经元细胞损伤。我们试图证明急性缺血性中风（AIS）后总抗氧化能力（TAC）水平与预后之间的关联。
我们纳入了60例因AIS入院的患者（36例女性和24例男性），另外还有30例年龄和性别匹配的健康对照。在中风发作第1天测量TAC水平，评估TAC水平、中风亚型以及出院时基于美国国立卫生研究院卒中量表和改良Rankin量表的临床预后之间的关系。
AIS患者的TAC水平显著低于对照组（P <.001），大血管脑梗死患者的TAC水平远低于小血管梗死患者。我们研究了TAC浓度是否反映缺血性中风的严重程度和预后，发现预后不良组的TAC浓度显著低于预后良好组（P <.001）。
我们的研究结果表明，与TAC和氧化应激相关的生化变化可能被视为缺血性脑损伤和缺血性中风临床预后的标志物。
