Yasak Ibrahim Halil, Yilmaz Mustafa, Goktekin Mehmet C, Giden Ramazan, Koyuncu İsmail
Department of Emergency Medicine, Faculty of Medicine, Harran University, Sanlıurfa, TUR.
Department of Emergency Medicine, Faculty of Medicine, Firat University, Elaziğ, TUR.
Cureus. 2022 Nov 30;14(11):e32042. doi: 10.7759/cureus.32042. eCollection 2022 Nov.
Ongoing research aims to investigate blood-based biomarkers and use them in acute ischaemic stroke (AIS) diagnosis and management of patients with AIS.
The purpose of the present study was to investigate the meteorin-like protein (Metrnl) levels secreted by adipose tissue in patients with AIS.
The study groups included healthy controls (n=30) and patients diagnosed with AIS via magnetic resonance imaging (MRI) in the emergency department (n=35) during the one-year period. The basic laboratory values and Metrnl, total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) levels of the patients were compared. The Metrnl levels were measured using enzyme-linked immunosorbent assays.
In the present study, the Metrnl (p=0.001) and TAC (p=0.009) levels decreased significantly, whereas the TOS (p<0.001) and OSI (p<0.001) levels increased significantly in the patients with AIS compared to the healthy controls. Furthermore, a cut-off value of ≤1.63% meteorin-like protein rendered the sensitivity and specificity rates of 91.43% and 71.43%, respectively, in the patients with AIS. In addition, there was a significant negative correlation between the decreased meteorin-like protein levels and the infarct diameter in patients with AIS.
In patients with AIS, the meteorin-like protein levels decreased inversely with the infarct diameter, and at the same time, there was an increase in TOS and OSI levels and a decrease in TAC levels.
正在进行的研究旨在调查基于血液的生物标志物，并将其用于急性缺血性卒中（AIS）的诊断和AIS患者的管理。
本研究的目的是调查AIS患者脂肪组织分泌的类陨石蛋白（Metrnl）水平。
研究组包括健康对照组（n = 30）和在一年期间于急诊科通过磁共振成像（MRI）诊断为AIS的患者（n = 35）。比较了患者的基本实验室值以及Metrnl、总抗氧化能力（TAC）、总氧化状态（TOS）和氧化应激指数（OSI）水平。使用酶联免疫吸附测定法测量Metrnl水平。
在本研究中，与健康对照组相比，AIS患者的Metrnl（p = 0.001）和TAC（p = 0.009）水平显著降低，而TOS（p < 0.001）和OSI（p < 0.001）水平显著升高。此外，类陨石蛋白≤1.63%的临界值在AIS患者中的灵敏度和特异度分别为91.43%和71.43%。此外，AIS患者中类陨石蛋白水平降低与梗死直径之间存在显著负相关。
在AIS患者中，类陨石蛋白水平与梗死直径呈负相关，同时，TOS和OSI水平升高，TAC水平降低。
