Duncan P M
Psychopharmacology (Berl). 1986;90(4):543-7. doi: 10.1007/BF00174076.
Rats were trained to discriminate between two compound stimulus arrays that included exteroceptive (ES) and interoceptive (IS) stimulus components. The ES components were illumination and tactile cues, and the IS components were produced by d-amphetamine (A) or Na pentobarbital (P) treatment (drug versus drug discrimination). The relative ES-IS strength was then determined by testing with "mismatched" stimulus arrays consisting of combinations of ES and IS components that had not been presented simultaneously during training. Additional tests were done with ES only (no drug treatments). At training doses of 0.8 mg/kg A versus 10 mg/kg P, the ES were less salient than, but did share stimulus control with, the stronger IS components. In a second group, trained with lower doses (0.5 mg/kg A versus 4 mg/kg P), the ES were much more salient than the IS, although again, both types of stimuli did acquire some control. This dose-related sharing of stimulus control between ES and IS components is similar to relationships among components of compound arrays consisting entirely of ES, and thus further illustrates similarity between drug-produced and exteroceptive stimuli.
训练大鼠区分两个复合刺激阵列，这些阵列包括外感受性（ES）和内感受性（IS）刺激成分。ES成分是光照和触觉线索，而IS成分是由右旋苯丙胺（A）或戊巴比妥钠（P）处理产生的（药物与药物辨别）。然后通过用“不匹配”刺激阵列进行测试来确定相对的ES-IS强度，该阵列由训练期间未同时呈现的ES和IS成分组合而成。还仅用ES（无药物处理）进行了额外测试。在训练剂量为0.8 mg/kg A与10 mg/kg P时，ES比更强的IS成分不那么突出，但确实共享刺激控制。在第二组中，用较低剂量（0.5 mg/kg A与4 mg/kg P）进行训练，ES比IS突出得多，尽管同样，两种类型的刺激都确实获得了一些控制。ES和IS成分之间这种与剂量相关的刺激控制共享类似于完全由ES组成的复合阵列成分之间的关系，因此进一步说明了药物产生的刺激与外感受性刺激之间的相似性。
