Jones C N, Grant L D, Vospalek D M
Psychopharmacologia. 1976;46(1):59-64. doi: 10.1007/BF00421550.
Three groups of rats were trained on a two-lever operant discrimination using d-amphetamine (0.8, 1.6 or 2.4 mg/kg) and saline as cues. Reinforcement of responding on one lever was associated with the drug and reinforcement on the other lever was associated with saline. Following acquisition, behavioral control was evaluated during 10-min extinction tests at 0, 15, 30, 60, 90, 120, 180 or 240 min after injection of drug or saline. Onset of the stimulus properties of d-amphetamine occurred within 10 min and maximal effects were attained by 15-30 min post-injection. Drug effects were minimal or absent 2-4 h after administration. The time course for all doses of d-amphetamine was identical when each group was tested iwth its respective training dose. When subjects were tested with doses other than their training dose, the time course of the drug effect varied as a function of training dose, test dose and time after injection.
将三组大鼠训练至能在双杠杆操作辨别实验中，以右旋苯丙胺（0.8、1.6或2.4毫克/千克）和生理盐水作为线索进行区分。对一个杠杆的反应强化与药物相关，而对另一个杠杆的反应强化则与生理盐水相关。习得之后，在注射药物或生理盐水后的0、15、30、60、90、120、180或240分钟进行10分钟的消退测试，以此评估行为控制情况。右旋苯丙胺的刺激特性在10分钟内出现，注射后15 - 30分钟达到最大效果。给药后2 - 4小时药物效果最小或不存在。当每组大鼠用各自的训练剂量进行测试时，所有剂量的右旋苯丙胺的时间进程是相同的。当用训练剂量以外的剂量对实验对象进行测试时，药物效应的时间进程会因训练剂量、测试剂量和注射后的时间而有所不同。
