Järbe T U, Johansson B
Behav Neurosci. 1984 Aug;98(4):686-94. doi: 10.1037//0735-7044.98.4.686.
Interactions between drug discriminative stimuli (based on 5.6 mg/kg and 10 mg/kg pentobarbital) and exteroceptive stimuli (visual and auditory) were studied in a T-maze. In three groups, visual stimuli (light vs. dark) were differentially paired with drug stimuli; the fourth group discriminated combinations of tonal frequencies (1 kHz or 10 kHz) and the presence or absence of pentobarbital. (10 mg/kg). In general, visual stimuli controlled choice behavior (left or right turn) to a greater extent than did the drug training stimuli, whereas the auditory stimuli exerted no apparent control over the pentobarbital stimulus in Group 4. Tests with doses higher than the training doses indicated augmented stimulus control by the drug dimension in two groups (Group 1, 10 mg/kg pentobarbital vs. saline; Group 2, 5.6 mg/kg vs. 10 mg/kg pentobarbital) but not in the third group (5.6 mg/kg pentobarbital vs. saline) in the "conflict" situation, that is, the exteroceptive conditions signaled one response whereas the drug stimulus signaled the opposite response. Discrimination training with only one of the stimulus dimensions resulted in stimulus control in the following order: 10 mg/kg vs. saline greater than 5.6 mg/kg vs. saline greater than 1 kHz vs. 10 kHz, results indicating that the auditory stimuli were of marginal significance. In conclusion, drugs can complete with exteroceptive, visual stimuli for associative strength.
在T型迷宫中研究了药物辨别刺激（基于5.6毫克/千克和10毫克/千克戊巴比妥）与外感受性刺激（视觉和听觉）之间的相互作用。在三组中，视觉刺激（亮与暗）与药物刺激进行差异配对；第四组辨别音调频率（1千赫或10千赫）的组合以及戊巴比妥（10毫克/千克）的有无。一般来说，视觉刺激比药物训练刺激在更大程度上控制选择行为（左转或右转），而听觉刺激对第4组中的戊巴比妥刺激没有明显控制作用。用高于训练剂量的剂量进行测试表明，在“冲突”情况下，即外感受性条件指示一种反应而药物刺激指示相反反应时，两组（第1组，10毫克/千克戊巴比妥与生理盐水；第2组，5.6毫克/千克与10毫克/千克戊巴比妥）中药物维度的刺激控制增强，但第三组（5.6毫克/千克戊巴比妥与生理盐水）没有。仅用一种刺激维度进行辨别训练导致刺激控制的顺序如下：10毫克/千克与生理盐水大于5.6毫克/千克与生理盐水大于1千赫与10千赫，结果表明听觉刺激的意义不大。总之，药物可以与外感受性视觉刺激竞争联想强度。
